The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Rat liver peroxisomes catalyze the beta oxidation of fatty acids.
Open accessAbstract
Peroxisomes were purified by differential and equilibrium density centrifugation from the livers of rats treated with clofibrate to enhance their peroxisomal system of fatty acid oxidation. These purified peroxisomes were tested for the presence of crotonase, beta-hydroxybutyryl-CoA dehydrogenase and thiolase using spectroscopic techniques that utilize the characteristic absorption bands of the appropriate 4-carbon acyl-CoA substrates. All three enzymes were found. Analysis of the fractions from equilibrium density centrifugation revealed major peaks of these enzyme activities in peroxisomes and excluded contamination by mitochondria as an explanation of the results. In the presence of excess CoA the purified peroxisomes oxidized palmitoyl-CoA to acetyl-CoA, and reduced NAD, with a 1:5:5 stoichiometry. The peroxisomes were inactive with butyryl-CoA and less active with octanoyl-CoA than with lauroyl-CoA or palmitoyl-CoA; they appear specialized for the beta oxidation of long chain fatty acids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1987) · Comparative Biochemistry and Physiology Part A: Physiology · doi:10.1016/0300-9629(87)90411-7 · Cited by 2,958
Peroxisomes (microbodies and related particles).
De Duve, C., & Baudhuin, P. (1966) · Physiological Reviews · doi:10.1152/physrev.1966.46.2.323 · Cited by 1,666
A MICROSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CYTOCHROME OXIDASE
Cooperstein, S. J., & Lazarow, A. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)44883-1 · Cited by 1,352
Lazarow, P. B., & De Duve, C. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.6.2043 · Cited by 1,137
Self-citationLeighton, F., Poole, B., Beaufay, H., Baudhuin, P., Coffey, J. W., Fowler, S., & De Duve, C. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.37.2.482 · Cited by 1,116
FRITZ, I. B. (1963) · Advances in Lipid Research · doi:10.1016/b978-1-4831-9937-5.50014-4 · Cited by 446
The Subcellular Distribution of Carnitine Acyltransferases in Mammalian Liver and Kidney
Markwell, M. A. K., McGroarty, E. J., Bieber, L. L., & Tolbert, N. E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43946-x · Cited by 404
Enzymes of fatty acid metabolism
Lynen, F., & Ochoa, S. (1953) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(53)90149-8 · Cited by 395
TISSUE FRACTION-PAST AND PRESENT
de Duve, C. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.50.1.20d · Cited by 340
β Oxidation in Glyoxysomes from Castor Bean Endosperm
Cooper, T. G., & Beevers, H. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83402-0 · Cited by 330
Cited by
Depletion of intracellular calcium stores activates a calcium current in mast cells
Hoth, M., & Penner, R. (1992) · Nature · doi:10.1038/355353a0 · Cited by 1,751
Metabolic aspects of peroxisomal β-oxidation
Osmundsen, H., Bremer, J., & Pedersen, J. I. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90089-z · Cited by 278
Adrenoleukodystrophy: Survey of 303 cases: Biochemistry, diagnosis, and therapy
Moser, H. W., Moser, A. E., Singh, I., & O'Neill, P. (1984) · Annals of Neurology · doi:10.1002/ana.410160603 · Cited by 259
Peroxisomal fatty acid β-oxidation in HepG2 cells
Watkins, P. A., Ferrell, E. V., Pedersen, J. I., & Hoefler, G. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90419-j · Cited by 86
Very long chain fatty acid-containing lipids: A decade of novel insights from the study of ELOVL4.
Yeboah, G. K., Lobanova, E. S., Brush, R. S., & Agbaga, M.-P. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100030 · Cited by 69
Metadata
- Authors
- Lazarow, P. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1978-03
- Volume
- 253
- Issue
- 5
- Pages
- 1522-1528
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1573886742
- Cited by
- 607
- References
- 16
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Rat liver peroxisomes catalyze the beta oxidation of fatty acids. https://app.cochat.ai/papers/10.1016/s0021-9258(17)34897-4
- The paper
- Lazarow, P. B. (1978). Rat liver peroxisomes catalyze the beta oxidation of fatty acids. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)34897-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
