The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin.
Open accessAbstract
Plasma kallikrein was found to be a good activator of pro-urokinase, the inactive zymogen form of urokinase. The complete activation of pro-urokinase by plasma kallikrein was obtained in 2 h with an enzyme/substrate weight ratio of 1/30. The rate of activation of pro-urokinase by plasma kallikrein was comparable to that catalyzed by plasmin and trypsin. The rate of activation of pro-urokinase by factor XIIa was approximately one-seventh of that by plasma kallikrein. The activation of the zymogen was due to the cleavage of a single internal peptide bond, resulting in the conversion of a single chain pro-urokinase (Mr = 55,000) into two-chain urokinase (Mr = 33,000 and 22,000), and these two chains were linked by a disulfide bond(s). These results indicate an important role of plasma kallikrein for the activation of pro-urokinase in the factor XII-dependent intrinsic pathway of fibrinolysis. Thrombin also converted pro-urokinase to a two-chain form that was not activatable by plasmin, plasma kallikrein, and factor XIIa. Thrombin specifically cleaved the Arg 156-Phe 157 bond which is located 2 residues prior to the activation site of Lys 158-Ile 159.
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Cites
Structure of human factor VIII
Vehar, G. A., Keyt, B., Eaton, D., Rodriguez, H., O'Brien, D. P., Rotblat, F., Oppermann, H., Keck, R., Wood, W. I., Harkins, R. N., et al. (1984) · Nature · doi:10.1038/312337a0 · Cited by 883
GÜNZLER, W. A., STEFFENS, G. J., ÖTTING, F., KIM, S.-M. A., FRANKUS, E., & FLOHÉ, L. (1982) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1982.363.2.1155 · Cited by 312
Nielsen, L. S., Hansen, J. G., Skriver, L., Wilson, E. L., Kaltoft, K., Zeuthen, J., & Danoe, K. (1982) · Biochemistry · doi:10.1021/bi00268a014 · Cited by 257
Relationship between tissue plasminogen activator and the activators in blood and vascular wall
Rijken, D. C., Wijngaards, G., & Welbergen, J. (1980) · Thrombosis Research · doi:10.1016/0049-3848(80)90204-2 · Cited by 247
Activation of plasminogen by human plasma kallikrein
Colman, R. W. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90278-2 · Cited by 216
Kasai, S., Arimura, H., Nishida, M., & Suyama, T. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39035-x · Cited by 133
Self-citationMandle, R. J., & Kaplan, A. P. (1979) · Blood · doi:10.1182/blood.v54.4.850.850 · Cited by 90
Miles, L. A., Greengard, J. S., & Griffin, J. H. (1983) · Thrombosis Research · doi:10.1016/0049-3848(83)90244-x · Cited by 87
Proteolytic activation of tissue plasminogen activator by plasma and tissue enzymes
Ichinose, A., Kisiel, W., & Fujikawa, K. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80779-6 · Cited by 83
Self-citationTissot, J., Schneider, P., Hauert, J., Rüegg, M. A., Kruithof, E. K. O., & Bachmann, F. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110733 · Cited by 76
Cited by
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
Saksela, O., & Rifkin, D. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.000521 · Cited by 818
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
Bugge, T. H., Flick, M. J., Daugherty, C. C., & Degen, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.7.794 · Cited by 438
Takeuchi, T., Harris, J. L., Huang, W., Yan, K. W., Coughlin, S. R., & Craik, C. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002941200 · Cited by 435
Directed Plasminogen Activation at the Surface of Normal and Malignant Cells
(1991) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)61002-7 · Cited by 281
Alitalo, R. (1990) · Leukemia Research · doi:10.1016/0145-2126(90)90002-q · Cited by 152
Metadata
- Authors
- Ichinose, A., Fujikawa, K., & Suyama, T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 261
- Issue
- 8
- Pages
- 3486-3489
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1493910160
- Cited by
- 383
- References
- 10
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ichinose, A., Fujikawa, K., & Suyama, T. (1986). The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)35674-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
