The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
Open accessAbstract
Plasminogen (Plg)-deficient mice were generated to define the physiological roles of this key fibrinolytic protein and its proteolytic derivatives, plasmin and angiostatin, in development, hemostasis, and reproduction. Plg-/- mice complete embryonic development, survive to adulthood, and are fertile. There is no evidence of fetal loss of Plg-/- mice based on the Mendelian pattern of transmission of the mutant Plg allele. Furthermore, embryonic development continues to term in the absence of endogenous, sibling-derived, or maternal Plg. However, Plg-/- mice are predisposed to severe thrombosis, and young animals developed multiple spontaneous thrombotic lesions in liver, stomach, colon, rectum, lung, pancreas, and other tissues. Fibrin deposition in the liver was a uniform finding in 5- to 21-week-old mice, and ulcerated lesions in the gastrointestinal tract and rectal tissue were common. A remarkable finding, considering the well-established linkage between plasmin and the proteolytic activation of plasminogen activators, was that the level of active urokinase-type plasminogen activator in urine was unaffected in Plg-/- mice. Therefore, Plg plays a pivotal role in fibrinolysis and hemostasis but is not essential for urokinase proenzyme activation, development, or growth to sexual maturity.
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Self-citationPlasminogen is a critical host pathogenicity factor for group A streptococcal infection
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Metadata
- Authors
- Bugge, T. H., Flick, M. J., Daugherty, C. C., & Degen, J. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1995-04-01
- Volume
- 9
- Issue
- 7
- Pages
- 794-807
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2030575994
- Cited by
- 438
- References
- 50
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Bugge, T. H., Flick, M. J., Daugherty, C. C., & Degen, J. L. (1995). Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes & Development. https://doi.org/10.1101/gad.9.7.794
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