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Cited by 472

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The murine transforming growth factor-beta precursor.

Open access
Derynck, R, Jarrett, J A, Chen, E Y, Goeddel, D V·1986·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)38511-3
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Abstract

Transforming growth factor-beta (TGF-beta) is a homodimeric polypeptide which can act, often in cooperation with other growth factors, as a mitogenic factor for a variety of cells. TGF-beta can also exert growth inhibitory activity on many other cell lines. We have isolated cDNAs coding for the murine TGF-beta cDNA precursor. The deduced amino acid sequence localizes the 112-amino acid long TGF-beta monomer to the C terminus of the precursor. Two areas of the precursor exhibit a marked degree of homology to the human counterpart. One of these regions comprises the mature TGF-beta monomer, while the other corresponds to the NH2 terminus of the precursor and suggests an important biological function for this area. Northern hybridization results identify a major 2.5-kilobase TGF-beta mRNA and several minor TGF-beta mRNA species.

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Metadata

Authors
Derynck, R., Jarrett, J. A., Chen, E. Y., & Goeddel, D. V.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1986-04
Volume
261
Issue
10
Pages
4377-4379
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)38511-3
OpenAlex
W1608791497
Cited by
472
References
0
FWCI
13.54
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The murine transforming growth factor-beta precursor. https://app.cochat.ai/papers/10.1016/s0021-9258(17)38511-3
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Derynck, R., Jarrett, J. A., Chen, E. Y., & Goeddel, D. V. (1986). The murine transforming growth factor-beta precursor. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)38511-3

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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