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Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

Piguet, Pierre F., Collart, Martine A., Grau, Georges E., Sappino, André-P., Vassalli, Pierre·1990·Nature
DOI 10.1038/344245a0
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Abstract

The deposition of silica particles in the lung of man or experimental animals leads to silicosis, a disease of progressive respiratory failure caused by a fibrotic reaction. It has long been suspected that the phagocytosis of silica by pulmonary macrophages induces the secretion of fibrogenic factors. Several potentially fibrogenic cytokines released by macrophages have been identified, including interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF), platelet-derived growth factor, basic fibroblast growth factor and transforming growth factor-beta (TGF-beta). Here we show that TNF plays an important part in silica-induced pulmonary fibrosis in mice in that (1) a single instillation of silica leads to a marked increase in the level of lung TNF messenger RNA which lasts for greater than 70 days, while there are no obvious changes in the amounts of IL-1 alpha or TGF-beta mRNAs; and (2) silica-induced collagen deposition is almost completely prevented by anti-TNF antibody, but is significantly increased by continuous infusion of mouse recombinant TNF.

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Research works printed but not linked: 25

  1. Bowden, D. H. Expl. Lung Res. 12, 89–107 (1987). · DOI
  2. Heppleston, A. G. & Styles, J. A. Nature 214, 521–522 (1967). · DOI
  3. Schmidt, J. A., Mizel, S. B., Cohen, D. & Green, I. J. Immun. 128, 2177–2182 (1982). · DOI
  4. Sugarman, B. J., Aggarwal, B. B., Figari, I. S. & Palladino, M. A. Science 230, 943–945 (1985). · DOI
  5. Ross, R., Raines, E. W. & Bowen-Pope, D. F. Cell 46, 155–169 (1986). · DOI
  6. Folkman, J. & Klagsbrun, M. Science 235, 442–447 (1987). · DOI · Paper page
  7. Roberts, A. B. et al. Proc. natn. Acad. Sci. U.S.A. 83, 4176–4171 (1986). · DOI
  8. Dauber, J. J. H., Rossman, M. D., Pietra, G. G., Jimenez, S. A. & Daniele, R. P. Am. J. Path. 101, 595–612 (1980).
  9. Casey, T. W., Duncan, L. M. & Unanue, E. R. J. Immun. 142, 3469–3476 (1989). · DOI
  10. Ruff, M. R. & Gifford, G. E. J. Immun. 126, 1671–1677 (1980). · DOI
  11. Huszar, G., Maiocco, J. & Naftolin, F. Analyt. Biochem. 105, 424–429 (1979). · DOI
  12. Broukaert, P., Spriggs, D. R., Demetri, G., Kufe, D. W. & Fiers, W. J. exp. Med. 169, 2257–2262 (1989). · DOI
  13. Piguet, P. F., Grau, G. E. & Vassalli, P. Am. J. Path. 136, 1990–1998 (1990).
  14. Tracey, K. J. et al. J. exp. Med. 167, 1211–1227 (1988). · DOI
  15. Bowden, D. H. & Adamson, I. Y. R. J. Path. 144, 149–161 (1984). · DOI
  16. Piguet, P. F., Collart, M. A., Grau, G. E., Kapanci, Y. & Vassalli, P. J. exp. Med. 170, 655–663 (1989). · DOI
  17. Hubbard, A. K. Lab. Invest. 61, 46–50 (1989).
  18. Khalil, N., Bereznay, O., Sporn, M. & Greenberg, A. J. exp. Med. 170, 727–737 (1989). · DOI · Paper page
  19. Hoyt, D. G. & Lazo, J. S. J. Pharmac. exp. Ther. 246, 765–770 (1989).
  20. Schmidt, J. A., Oliver, C. N., Lepe-Zuniga, J. L., Green, I. & Gery, I. J. clin. Invest. 73, 1462–1472 (1984). · DOI
  21. Snider, D. E. Am. Rev. Respir. Dis. 118, 455–460 (1978).
  22. Kindler, V., Sappino, A. P., Grau, G. E., Piguet, P. F. & Vasssalli, P. Cell 56, 731–740 (1989). · DOI
  23. Collart, M. A., Belin, D., Vassalli, J. D., de Kossodo, S., & Vassalli, P. J. exp. Med. 163, 2113–2118 (1987).
  24. Derynck, R., Jarret, J. A., Chen, E. Y. & Goeddel, D. V. J. biol. Chem. 261, 4377–4379 (1986). · DOI
  25. Sappino, A. P., Huarte, J., Belin, D. & Vassalli, J. D. J. Cell Biol. 109, 2471–2479 (1989). · DOI

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Metadata

Authors
Piguet, P. F., Collart, M. A., Grau, G. E., Sappino, A.-P., & Vassalli, P.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1990-03
Volume
344
Issue
6263
Pages
245-247
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/344245a0
Cited by
454
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. https://app.cochat.ai/papers/10.1038/344245a0
The paper
Piguet, P. F., Collart, M. A., Grau, G. E., Sappino, A.-P., & Vassalli, P. (1990). Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature. https://doi.org/10.1038/344245a0