The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.
Open accessAbstract
The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.
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“oxytocin-neurophysin I (OXT) encodes the oxytocin prepropeptide containing the nonapeptide oxytocin and the carrier protein neurophysin-I16.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [16]
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Estrogen receptor signaling mechanisms
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L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer
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Marino, M., Galluzzo, P., & Ascenzi, P. (2006) · Current Genomics · doi:10.2174/138920206779315737 · Cited by 618
Oxytocin pathway gene networks in the human brain
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Metadata
- Authors
- Sausville, E., Carney, D., & Battey, J.
- Affiliations
- Walter Reed National Military Medical Center (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1985-08
- Volume
- 260
- Issue
- 18
- Pages
- 10236-10241
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2102290655
- Cited by
- 338
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 7
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- vasopressin gene, oxytocin gene, genetic linkage, neurophysin II, neurophysin I, small cell lung cancer, gene expression, exon-intron structure, gene cloning, mRNA synthesis
- MeSH terms
- Amino Acid Sequence, Arginine Vasopressin, Base Sequence, Cell Line, Cloning, Molecular, DNA Restriction Enzymes, Genes, Genetic Vectors, Humans, Genetic Linkage, Lung Neoplasms, Neurophysins, Oxytocin, Protein Precursors, Vasopressins
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