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Cited by 142Hormonal Regulation and HypertensionRenin-Angiotensin System StudiesIon channel regulation and function

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Role of calcium fluxes in the sustained phase of angiotensin II-mediated aldosterone secretion from adrenal glomerulosa cells.

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Kojima, I, Kojima, K, Rasmussen, H·1985·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)39349-3
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Abstract

When angiotensin II stimulates aldosterone secretion, it causes a rapid but transient mobilization of calcium from an intracellular pool and a sustained increase in the influx of calcium in adrenal glomerulosa cells. The present studies were undertaken to determine the respective roles of the two angiotensin II-induced changes in cellular calcium metabolism in modulating events during the sustained phase of cellular response which is thought to be mediated by the C-kinase branch of the calcium messenger system. The sustained response to angiotensin II is only 50% of maximal in cells pretreated with dantrolene in a concentration sufficient to inhibit the angiotensin II-induced mobilization of intracellular calcium. Also, if A23187 is added to cells simultaneously with 1-oleoyl-2-acetylglycerol (OAG), the aldosterone secretory response is similar to that seen after angiotensin II. However, if A23187 is added first and the transient aldosterone secretory response allowed to decay, and OAG then added, the sustained aldosterone secretory response is only 45-50% of maximal. Addition of the calcium channel agonist, BAY K 8644, with OAG leads to an aldosterone secretory response which is only 50% of maximal, but if upon addition of OAG and BAY K 8644 the cells are also exposed for 5 min to media containing 8 mM K+, then the sustained secretory response is maximal. These data imply that the initial transient rise in the [Ca2+] of the cell cytosol plays a role in determining the extent to which C-kinase is shifted from its calcium-insensitive to its calcium-sensitive form. The second group of experiments examined the relationship between the sustained angiotensin II-induced increase in plasma membrane calcium influx and the sustained aldosterone secretory response. The results show that in the presence of 1 microM nitrendipine or 2 mM extracellular K+, angiotensin II causes no increase in calcium influx and only a transient rather than a sustained increase in the rate of aldosterone secretion indicating that the sustained phase of the response is dependent upon a continued high rate of Ca2+ influx which regulates the rate of turnover of the activated C-kinase.

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Crossref · 10.1016/s0021-9258(17)39349-3

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Citations

Cites

Research works printed but not linked: 6

  1. Foster, 1983, Am. J. Physiol., 245, E281
  2. Kojima, 1985, Am. J. Physiol., 248, E36
  3. Kojima, 1984, Am. J. Physiol., 247, E645
  4. Rasmussen, 1984, Adv. Cyclic Nucleotide Res., 18, 159
  5. Snowdowne, 1984, Am. J. Physiol., 246, E198
  6. Vincenzi, 1983, Ann. N.Y. Acad. Sci., 356, 244

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Metadata

Authors
Kojima, I., Kojima, K., & Rasmussen, H.
Affiliations
Yale University (US)
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1985-08
Volume
260
Issue
16
Pages
9177-9184
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)39349-3
OpenAlex
W1546020694
Cited by
142
References
29
Citations by year
2023: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2
FWCI
17.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (5r01am019813-10)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
angiotensin II, aldosterone secretion, adrenal glomerulosa cells, calcium flux, calcium mobilization, protein kinase C, dantrolene, 1-oleoyl-2-acetylglycerol, Bay K 8644, nitrendipine, extracellular potassium
MeSH terms
Calcimycin, Adrenal Glands, Aldosterone, Angiotensin II, Animals, 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester, Calcium, Calcium Channel Blockers, Cattle, Dantrolene, Ion Channels, Kinetics, Models, Biological, Nifedipine, Nitrendipine, Potassium, In Vitro Techniques

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