The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Thyroid hormone regulation of beta-adrenergic receptor number.
Abstract
The effects of exogenous thyroid hormones (thyroxine and triiodothyronine) on beta-adrenergic receptors in the rat myocardium were investigated. The potent beta-adrenergic antagonist, (-)-[3H]dihydroalprenolol, was used to directly estimate the number and affinity of beta-adrenergic receptors in rat heart membranes from control and hyperthyroid rats. Cardiac membranes from hyperthyroid rats contained 196 +/- 7 fmol of (-)-[3H]dihydroalprenolol binding sites/mg of protein which was significantly (p less than 0.005) greater than the number of binding sites (89 +/- 5 fmol/mg of protein) present in control membranes. The equilibrium dissociation constant (KD) for the interaction of receptors with dihydroalprenolol was the same (2 to 15 nM) in membranes from control and hyperthyroid rats. Similarly, there was no significant difference between the control and hyperthyroid membranes in the affinity of the beta-adrenergic receptor binding sites for the beta-adrenergic agonist isoproterenol. The results of this study demonstrate that thyroid hormones can regulate the number of cardiac beta-adrenergic receptors. The increased numbers of receptors may be responsible, at least in part, for the enhanced catecholamine sensitivity of beta-adrenergic-coupled cardiac responses in the hyperthyroid state.
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“There is, however, considerable evidence that experimental thyrotoxicosis in animals causes an increase in myocardial β-adrenergic receptor numbers (26, 27).”
From Triiodothyronine-induced Thyrotoxicosis Increases Mononuclear Leukocyte β-Adrenergic Receptor Density in Man (1981) · cites this paper as [26]
Citations
Cites
Mukherjee, C., Caron, M. G., & Lefkowitz, R. J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.5.1945 · Cited by 379
Self-citationIdentification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.
Williams, L. T., Snyderman, R., & Lefkowitz, R. J. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108254 · Cited by 322
Self-citationMukherjee, C., Caron, M. G., Coverstone, M., & Lefkowitz, R. J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41249-0 · Cited by 251
Self-citationDependence of the lipolytic action of epinephrine in vitro upon thyroid hormone
Debons, A. F., & Schwartz, I. L. (1961) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39044-1 · Cited by 239
Adrenal Medullary and Thyroid Relationships
Harrison, T. S. (1964) · Physiological Reviews · doi:10.1152/physrev.1964.44.2.161 · Cited by 228
Target Tissue Receptors for Progesterone: The Influence of Estrogen Treatment1
TOFT, D. O., & O’MALLEY, B. W. (1972) · Endocrinology · doi:10.1210/endo-90-4-1041 · Cited by 192
Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding.
Alexander, R. W., Williams, L. T., & Lefkowitz, R. J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.4.1564 · Cited by 182
Self-citationWilliams, L. T., Jarett, L., & Lefkowitz, R. J. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33503-2 · Cited by 164
Self-citationDependence of renal (Na+ + k+)-adenosine triphosphatase activity on thyroid status
Lo, S. C., August, T. R., Liberman, U. A., & Edelman, I. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57010-7 · Cited by 158
beta-adrenergic receptors in rat liver: effects of adrenalectomy.
Wolfe, B. B., Harden, T. K., & Molinoff, P. B. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1343 · Cited by 148
Research works printed but not linked: 1
- Wildenthal, 1974, J. Pharmacol. Exp. Ther., 190, 272, 10.1016/S0022-3565(25)29918-9 · doi:10.1016/s0022-3565(25)29918-9
Cited by
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
Biondi, B. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4701 · Cited by 356
Ginsberg, A. M., Clutter, W. E., Shah, S. D., & Cryer, P. E. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110218 · Cited by 99
TSAI, J. S., & CHEN, A. (1978) · Nature · doi:10.1038/275138a0 · Cited by 58
Metadata
- Authors
- Williams, L. T., Lefkowitz, R. J., Watanabe, A. M., Hathaway, D. R., & Besch, H. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1977-04
- Volume
- 252
- Issue
- 8
- Pages
- 2787-2789
- ISSN
- 0021-9258
- Cited by
- 453
- References
- 21
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 15916 d)
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- Williams, L. T., Lefkowitz, R. J., Watanabe, A. M., Hathaway, D. R., & Besch, H. R. (1977). Thyroid hormone regulation of beta-adrenergic receptor number. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)40528-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
