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Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.
Open accessAbstract
Injection of frogs with beta-adrenergic catecholamines for 1-24 hr produces marked subsensitivity of the erythrocyte membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1.] to in vitro stimulation by isoproterenol. The subsensitization is specific for catecholamine stimulation, since basal and fluoride-stimulated enzyme activity are unaffected. Maximum isoproterenol-stimulated adenylate cyclase activity declines by 75% in the isoproterenol-treated animals (P less than 0.001). The concentration of isoproterenol causing one-half maximal activation of adenylate cyclase, however, is unaltered. (-)[3H]Alprenolol, a potent competitive beta-adrenergic antagonist, was used to study directly the beta-adrenergic receptor binding sites in the erythrocyte membranes from control and subsensitized animals. A highly significant (P less than 0.005) 60% fall in the number of the beta-adrenergic receptor binding sites ("specific"(-)[3H]alprenolol binding sites) in the treated animals was found. The binding affinity of the sites was not markedly altered. These data suggest that beta-adrenergic catecholamines are able to regulate catecholamine sensitivity of tissues in vivo, by regulating the properties of the beta-adrenergic receptor binding sites.
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Cited by
Belchetz, P. E., Plant, T. M., Nakai, Y., Keogh, E. J., & Knobil, E. (1978) · Science · doi:10.1126/science.100883 · Cited by 1,385
Sibley, D. R., & Lefkowitz, R. J. (1985) · Nature · doi:10.1038/317124a0 · Cited by 734
Self-citationDevelopment of β-adrenergic receptor subsensitivity by antidepressants
BANERJEE, S. P., KUNG, L. S., RIGGI, S. J., & CHANDA, S. K. (1977) · Nature · doi:10.1038/268455a0 · Cited by 722
Membrane Receptors and Hormone Action
Cuatrecasas, P., & Hollenberg, M. D. (1976) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60481-7 · Cited by 478
Thyroid hormone regulation of beta-adrenergic receptor number.
Williams, L. T., Lefkowitz, R. J., Watanabe, A. M., Hathaway, D. R., & Besch, H. R. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40528-x · Cited by 453
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Metadata
- Authors
- Mukherjee, C., Caron, M. G., & Lefkowitz, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-05
- Volume
- 72
- Issue
- 5
- Pages
- 1945-1949
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2029427837
- Cited by
- 379
- References
- 0
- FWCI
- 20.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Mukherjee, C., Caron, M. G., & Lefkowitz, R. J. (1975). Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.5.1945
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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