The DOI matches its Crossref record.
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
Open accessAbstract
A potent (Na,K)-ATPase inhibitor purified from "Sigma Grade* ATP has been identified as vanadium using electron probe microanalysis and confirmed by microwave-induced emission spectroscopy and electron paramagnetic resonance spectroscopy. Sodium orthovanadate (Na3 VO4) is identical with the purified inhibitor with respect to ultraviolet absorbance, migration on thin layer chromatography, and inhibition of (Na,K)-ATPase. The (Na,K)-ATPase is in-inhibited 50% by 40 nM Na3 VO4 under optimal conditions (28 mM Mg2+) and the inhibition is 100% reversible by millimolar concentrations of norepinephrine. The physiological significance of this inhibition is discussed in relation to vanadium concentrations in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Solomon, M. J., Glotzer, M., Lee, T. H., Philippe, M., & Kirschner, M. W. (1990) · Cell · doi:10.1016/0092-8674(90)90504-8 · Cited by 688
Vanadium compounds in medicine
Pessoa, J. C., Etcheverry, S., & Gambino, D. (2015) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2014.12.002 · Cited by 561
Heffetz, D., Bushkin, I., Dror, R., & Zick, Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39885-0 · Cited by 429
Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side
CANTLEY, L. C., RESH, M. D., & GUIDOTTI, G. (1978) · Nature · doi:10.1038/272552a0 · Cited by 375
Self-citationActivation of Na+ and K+ pumping modes of (Na, K)-ATPase by an oscillating electric field
Liu, D. S., Astumian, R. D., & Tsong, T. Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39108-2 · Cited by 199
Metadata
- Authors
- Cantley, L. C., Josephson, L., Warner, R., Yanagisawa, M., Lechene, C., & Guidotti, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1977-11
- Volume
- 252
- Issue
- 21
- Pages
- 7421-7423
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1520021552
- Cited by
- 831
- References
- 0
- FWCI
- 57.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. https://app.cochat.ai/papers/10.1016/s0021-9258(17)40978-1
- The paper
- Cantley, L. C., Josephson, L., Warner, R., Yanagisawa, M., Lechene, C., & Guidotti, G. (1977). Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)40978-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
