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Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates.
Open accessAbstract
Two procedures were devised to examine initial events in the glucocorticoid-regulated transcription of integrated murine mammary tumor virus (MTV) DNA sequences. First, cells in monolayer culture were exposed for brief periods to dexamethasone and then permeabilized in situ with digitonin to allow entry of 32P-labeled ribonucleoside triphosphates and measurement of transcription rates. The results revealed that the rate of MTV RNA synthesis is stimulated selectively by dexamethasone after an apparent lag of approximately equal to 1 min and is half-maximal by 8-9 min. Second, the time course of transcription elongation was monitored by quantitating in single strand nuclease protection assays the accumulation of RNA sequences from different regions of the 7.8-kilobase MTV transcription unit. These experiments suggested that the rate of MTV RNA elongation in the presence of hormone does not differ substantially from elongation rates calculated for other genes transcribed by RNA polymerase II. Moreover, dexamethasone increased in parallel and to the same extent the levels of RNA from various segments of the transcription unit, implying that transcripts are elongated across the MTV element at a constant rate. We conclude that glucocorticoids stimulate MTV transcription solely via a rapid and selective increase in the efficiency of transcription initiation.
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“By monitoring the appearance of RNA by in situ hybridization, nuclear run‐on, slot blot, or RT–PCR after expression activation, RNA Pol II speed was estimated between 1.1 kb/min and 4.8 kb/min (Ucker & Yamamoto, 1984; Thummel et al, 1990; Shermoen & O'Farrell, 1991; O'Brien & Lis, 1993; Tennyson et al, 1995; Femino et al, 1998; Femino et al, 2003; Hanisch et al, 2013).”
From RNA polymerase II speed: a key player in controlling and adapting transcriptome composition (2021) · cites this paper as Ucker & Yamamoto, 1984
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Cites
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Self-citationActivation of Nuclear RNA Polymerase by Sarkosyl
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- Anderson, 1984, Vol. 3B, 169
- Firestone, 1983, Mol. Cell. Biol., 3, 149
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Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.
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Self-citationAutoinhibition with Transcriptional Delay
Lewis, J. H. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00534-7 · Cited by 736
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Eisenberg, E., & Levanon, E. Y. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00140-9 · Cited by 699
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Metadata
- Authors
- Ucker, D. S., & Yamamoto, K. R.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1984-06
- Volume
- 259
- Issue
- 12
- Pages
- 7416-7420
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1483243107
- Cited by
- 190
- References
- 28
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- mammary tumor virus, glucocorticoids, dexamethasone, transcription initiation, transcription elongation, RNA polymerase II, transcription rate, transcriptional regulation, nuclease protection assay, digitonin permeabilization
- MeSH terms
- Animals, Base Sequence, Dexamethasone, Digitonin, Endonucleases, Mammary Tumor Virus, Mouse, Nucleic Acid Hybridization, RNA, Viral, Time Factors, Transcription, Genetic, Single-Strand Specific DNA and RNA Endonucleases, Rats
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