The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The sodium channel from rat brain. Purification and subunit composition.
Open accessAbstract
A procedure is described for purification of the sodium channel 1380-fold from rat brain to essential homogeneity. The channel is solubilized in Triton X-100 and stabilized by addition of phosphatidylcholine and 10 mM CaCl2. It is purified by sequential chromatography on DEAE-Sephadex, hydroxylapatite, and wheat germ agglutinin/Sepharose followed by sedimentation through sucrose gradients. The final preparation binds 2910 pmol of saxitoxin (STX)/mg of protein or 0.9 mol of STX/mol of sodium channel of Mr approximately 316,000. Three polypeptide subunits comprise 90% of the silver stain intensity on sodium dodecyl sulfatepolyacrylamide gels of the pure protein and migrate as a stoichiometric complex coincident with STX-binding activity in sucrose gradient sedimentation: alpha with Mr approximately 260,000, beta 1 with Mr approximately 39,000, and beta 2 with Mr approximately 37,000. The alpha subunit, both purified and in intact synaptosomes, is shown to behave anomalously during sodium dodecyl sulfate-polyacrylamide gel electrophoresis exhibiting an unusually high extrapolated electrophoretic free mobility. A subunit stoichiometry of alpha 1(beta 1)1(beta 2)1 is proposed.
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Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes
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Self-citationChemicals as tools in the study of excitable membranes.
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Catterall, W. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224204 · Cited by 719
Self-citationProtein Phosphorylation and Neuronal Function
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Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins
LIPPINCOTTSCHWARTZ, J. (1988) · Cell · doi:10.1016/0092-8674(88)90553-3 · Cited by 493
Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons
Westenbroek, R. E., Merrick, D. K., & Catterall, W. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90238-9 · Cited by 477
Self-citationSubcellular segregation of two A-type K+ channel proteins in rat central neurons
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Metadata
- Authors
- Hartshorne, R. P., & Catterall, W. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1984-02
- Volume
- 259
- Issue
- 3
- Pages
- 1667-1675
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1653329430
- Cited by
- 356
- References
- 19
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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