The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Voltage‐gated sodium channels at 60: structure, function and pathophysiology
Open accessAbstract
Abstract Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other excitable cells. The sodium current that initiates the nerve action potential was discovered by Hodgkin and Huxley using the voltage clamp technique in their landmark series of papers in The Journal of Physiology in 1952. They described sodium selectivity, voltage‐dependent activation and fast inactivation, and they developed a quantitative model for action potential generation that has endured for many decades. This article gives an overview of the legacy that has evolved from their work, including development of conceptual models of sodium channel function, discovery of the sodium channel protein, analysis of its structure and function, determination of its structure at high resolution, definition of the mechanism and structural basis for drug block, and exploration of the role of the sodium channel as a target for disease mutations. Structural models for sodium selectivity and conductance, voltage‐dependent activation, fast inactivation and drug block are discussed. A perspective for the future envisions new advances in understanding the structural basis for sodium channel function, the role of sodium channels in disease and the opportunity for discovery of novel therapeutics.
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Cites
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Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004717 · Cited by 2,491
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The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004719 · Cited by 1,600
An SCN9A channelopathy causes congenital inability to experience pain
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The crystal structure of a voltage-gated sodium channel
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Mayakonda, A., Lin, D.-C., Assenov, Y., Plass, C., & Koeffler, H. P. (2018) · Genome Research · doi:10.1101/gr.239244.118 · Cited by 4,935
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Dong, K., Du, Y., Rinkevich, F., Nomura, Y., Xu, P., Wang, L., Silver, K., & Zhorov, B. S. (2014) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2014.03.012 · Cited by 548
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McCormack, K., Santos, S., Chapman, M. L., Krafte, D. S., Marron, B. E., West, C. W., Krambis, M. J., Antonio, B. M., Zellmer, S. G., Printzenhoff, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220844110 · Cited by 244
Metadata
- Authors
- Catterall, W. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2012-04-27
- Volume
- 590
- Issue
- 11
- Pages
- 2577-2589
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2163151214
- Cited by
- 719
- References
- 86
- FWCI
- 20.33
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
