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Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.
Open accessAbstract
The addition of thrombin to human platelets prelabeled with 32Pi led to significant loss of radioactivity in phosphatidylinositol 4,5-bisphosphate within 5 s, followed by recovery or even increase by 2 min. Loss of label from phosphatidylinositol phosphate was much less marked. Stimulated loss of label from phosphatidylinositol was not seen, while labeled phosphatidate increased severalfold. The principal labeled water-soluble phosphates observed, in addition to 32Pi and [32P] ATP, co-migrated with inositol diphosphate and inositol triphosphate. This suggests that a pool of polyphosphoinositides is constantly undergoing phosphodiesteratic cleavage and resynthesis. Thrombin addition led to rapid increase in radioactivity in inositol triphosphate, but not in inositol diphosphate. We conclude that this early consequence of the thrombin-platelet interaction is the result of an increase in the phosphodiesteratic cleavage of phosphatidylinositol bisphosphate.
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Citations
Cited by
Inositol Trisphosphate, a Novel Second Messenger in Cellular Signal Transduction
Berridge, M. J., & Irvine, R. F. (1984) · Nature · doi:10.1038/312315a0 · Cited by 6,086
Rink, T. J., Sanchez, A., & Hallam, T. J. (1983) · Nature · doi:10.1038/305317a0 · Cited by 586
Sugimoto, Y., Whitman, M., Cantley, L. C., & Erikson, R. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.2117 · Cited by 462
Metadata
- Authors
- Agranoff, B. W., Murthy, P., & Seguin, E. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-02
- Volume
- 258
- Issue
- 4
- Pages
- 2076-2078
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1577793849
- Cited by
- 389
- References
- 0
- FWCI
- 29.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Agranoff, B. W., Murthy, P., & Seguin, E. B. (1983). Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)32882-5
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