Inositol Trisphosphate, a Novel Second Messenger in Cellular Signal Transduction
Abstract
There has recently been rapid progress in understanding receptors that generate intracellular signals from inositol lipids. One of these lipids, phosphatidylinositol 4,5-bisphosphate, is hydrolysed to diacylglycerol and inositol trisphosphate as part of a signal transduction mechanism for controlling a variety of cellular processes including secretion, metabolism, phototransduction and cell proliferation. Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
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InsP3 stimulates intracellular calcium release.
“The discovery of inositol 1,4,5-trisphosphate (InsP3) as a critical secondary messenger that stimulates intracellular calcium release [1] revolutionized our understanding of cellular signaling.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [1]
InsP3 mobilizes intracellular calcium release from the endoplasmic reticulum.
“Since Michael Berridge and colleagues’ seminal discovery in 1983 [2] that InsP3 mobilizes intracellular calcium release from the endoplasmic reticulum [1,2,3], extensive research has illuminated InsP3’s crucial roles in regulating diverse physiological processes.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [1]
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From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
“The discovery of inositol 1,4,5-trisphosphate (InsP3) as a critical secondary messenger that stimulates intracellular calcium release [1] revolutionized our understanding of cellular signaling.”
- Authors
- Berridge, M. J., & Irvine, R. F.
- Affiliations
- University of Cambridge (GB)
- Venue
- Nature
- Published
- 1984-11
- Volume
- 312
- Issue
- 5992
- Pages
- 315-321
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2068877244
- Cited by
- 6,086
- References
- 0
- Citations by year
- 2026: 21 · 2025: 36 · 2024: 26 · 2023: 36 · 2022: 20 · 2021: 34 · 2020: 33 · 2019: 30 · 2018: 29 · 2017: 26 · 2016: 29 · 2015: 38 · 2014: 48 · 2013: 48 · 2012: 49
- FWCI
- 38.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- inositol trisphosphate, second messengers, signal transduction, phosphatidylinositol 4,5-bisphosphate, diacylglycerol, protein kinase C, intracellular calcium release, phototransduction, secretion, cell proliferation
- MeSH terms
- Animals, Calcium, Cell Cycle, Cell Membrane, Diglycerides, Embryo, Mammalian, Humans, Inositol Phosphates, Oncogenes, Phosphatidylinositols, Sugar Phosphates, Vision, Ocular, GTP-Binding Proteins
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