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A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1.
Open accessAbstract
A series of glycolipid antigens reacting with the monoclonal antibody directed to the stage-specific embryonic antigen 1 was isolated and characterized from group O human erythrocyte membranes. A ceramide heptasaccharide (Structure 1), ceramide nonasaccharide (Structure 2), and ceramide decasaccharide (Structure 3) have been characterized (formula, see text) The main feature of this glycolipid series is its long core sugar chain with a nonbranched repeating N-acetyllactosamine (norpolylactosamine). This characteristic is in contrast to that of co-existing H-active glycolipid series in which the longer core structures are branched type repeating N-acetyllactosamine (isopolylactosamine). The reactivity of these glycolipids to monoclonal anti-stage-specific embryonic antigen 1 antibody varied proportionately to the length of their core sugar chains. A possible significance of these glycolipids as developmentally regulated antigens and as cancer-associated antigens was discussed.
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Citations
Cited by
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
Hakomori, S. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.003505 · Cited by 1,644
Self-citationBremer, E. G., Schlessinger, J., & Hakomori, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35954-9 · Cited by 706
Self-citationGlycosphingolipid antigens and cancer therapy
Hakomori, S.-I., & Zhang, Y. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90253-2 · Cited by 288
Self-citationFenderson, B. A., Zehavi, U., & Hakomori, S. (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.5.1591 · Cited by 286
Self-citationFukushi, Y., Nudelman, E., Levery, S. B., Hakomori, S., & Rauvala, H. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90993-2 · Cited by 280
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Metadata
- Authors
- Kannagi, R., Nudelman, E., Levery, S. B., & Hakomori, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 257
- Issue
- 24
- Pages
- 14865-14874
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1608212624
- Cited by
- 353
- References
- 0
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1. https://app.cochat.ai/papers/10.1016/s0021-9258(18)33363-5
- The paper
- Kannagi, R., Nudelman, E., Levery, S. B., & Hakomori, S. (1982). A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)33363-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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