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A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1.

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Kannagi, R, Nudelman, E, Levery, S B, Hakomori, S·1982·Journal of Biological Chemistry

Abstract

A series of glycolipid antigens reacting with the monoclonal antibody directed to the stage-specific embryonic antigen 1 was isolated and characterized from group O human erythrocyte membranes. A ceramide heptasaccharide (Structure 1), ceramide nonasaccharide (Structure 2), and ceramide decasaccharide (Structure 3) have been characterized (formula, see text) The main feature of this glycolipid series is its long core sugar chain with a nonbranched repeating N-acetyllactosamine (norpolylactosamine). This characteristic is in contrast to that of co-existing H-active glycolipid series in which the longer core structures are branched type repeating N-acetyllactosamine (isopolylactosamine). The reactivity of these glycolipids to monoclonal anti-stage-specific embryonic antigen 1 antibody varied proportionately to the length of their core sugar chains. A possible significance of these glycolipids as developmentally regulated antigens and as cancer-associated antigens was discussed.

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Metadata

Authors
Kannagi, R., Nudelman, E., Levery, S. B., & Hakomori, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1982-12
Volume
257
Issue
24
Pages
14865-14874
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1608212624
Cited by
353
References
0
FWCI
12.11
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1. https://app.cochat.ai/papers/10.1016/s0021-9258(18)33363-5
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Kannagi, R., Nudelman, E., Levery, S. B., & Hakomori, S. (1982). A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)33363-5

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