The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells.
Open accessAbstract
The effects of 1,25-dihydroxyvitamin D3 on growth, cell protein, and alkaline phosphatase were examined in cultures of a clonal osteoblast-like rat osteosarcoma cell line at different stages of phenotypic maturation, defined by the level of alkaline phosphatase activity. In "immature" cultures with low alkaline phosphatase specific activity, 1,25-dihydroxyvitamin D3 at 10(-8)-10(-7) M inhibited cell growth and elevated alkaline phosphatase activity; lower hormone concentrations had no effect. In cultures with higher alkaline phosphatase activity, the hormone had biphasic effects: at concentrations of 10(-8)-10(-7) M, 1,25-dihydroxyvitamin D3 inhibited growth and elevated alkaline phosphatase and total cell protein; however, lower hormone concentrations (10(-10) and 10(-9) M) reduced alkaline phosphatase activity. This effect was more pronounced in more "mature" cultures where half-maximum inhibition of alkaline phosphatase activity occurred near 10(-11) M. At this stage, the hormone caused a small increase in cell number. The data suggest that 1,25-dihydroxyvitamin D3 exerts differential effects on skeletal cells depending on their state of growth or maturation. This finding may offer new insights into the effects of 1,25-dihydroxyvitamin D3 on bone and may help resolve apparently conflicting experimental findings on the effects of the hormone on osteoblast-like cells in culture.
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Citations
Cites
Role of osteoblasts in hormonal control of bone resorption—A hypothesis
Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982
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Cited by
Estrone sulfate Is a Major source of local estrogen formation in human bone
Muir, M., Romalo, G., Wolf, L., Elger, W., & Schweikert, H.-U. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0049 · Cited by 41
Metadata
- Authors
- Majeska, R. J., & Rodan, G. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1982-04
- Volume
- 257
- Issue
- 7
- Pages
- 3362-3365
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1527157268
- Cited by
- 297
- References
- 1
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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