Role of osteoblasts in hormonal control of bone resorption—A hypothesis
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Bone resorption stimulation requires contact between osteoblastic and osteoclastic lineage cells.
“stimulation of bone resorption requires an interaction between cells of the osteoblastic and osteoclastic lineages”
From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [44]
Cites
Effect of osteoclast activating factor from human leukocytes on bone metabolism.
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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
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Pathogenesis of osteoporosis: concepts, conflicts, and prospects
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Evidence for osteocyte regulation of bone homeostasis through RANKL expression
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“Before the discovery of RANK, its ligand (RANKL) and its antagonist (osteoprotegerin), the development and the formation of osteoclasts were thought to be controlled by factors produced by osteoblasts and bone marrow stromal cells (162, 198).”
BackgroundMinireview: The OPG/RANKL/RANK System
Khosla, S. (2001) · Endocrinology · doi:10.1210/endo.142.12.8536 · Cited by 1,515 · see citing works
BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING
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The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.
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Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
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“The ability of cells within the osteoblast lineage to stimulate osteoclast formation and/or activity was proposed by Rodan and Martin in 1981 [38], but only recently has it become clear that this capacity was maintained and probably enhanced as osteoblasts mature into osteocytes [14,39].”
BackgroundOsteoprotegerin and RANKL regulate bone resorption, density, geometry and strength.
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Self-citationEphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts
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Self-citationStromal-Initiated Changes in the Bone Promote Metastatic Niche Development
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(Pre-)Osteoclasts Induce Retraction of Osteoblasts Before Their Fusion to Osteoclasts
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- Authors
- Rodan, G. A., & Martin, T. J.
- Affiliations
- University of Connecticut (US)
- The University of Melbourne (AU)
- Venue
- Calcified Tissue International
- Published
- 1981-12
- Volume
- 33
- Issue
- 1
- Pages
- 349-351
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2040337853
- Cited by
- 982
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 18 · 2019: 10 · 2018: 10 · 2017: 15 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 20 · 2012: 28
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- osteoblasts, bone resorption, hormonal regulation, bone remodeling, parathyroid hormone, calcitonin, osteoclasts
- MeSH terms
- Cyclic AMP, Animals, Bone Resorption, Calcitriol, Calcium, Humans, Models, Biological, Osteoblasts, Osteoclasts, Parathyroid Hormone, Prostaglandins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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