The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Signal transduction within the nucleus by mitogen-activated protein kinase.
Open accessAbstract
The nucleus is an important target of signal transduction by growth factor receptors that stimulate mitogen-activated protein (MAP) kinases. We tested the hypothesis that MAP kinases have a signaling role within the nucleus by examining the effect of the expression of a human MAP kinase isoform (p41mapk) in tissue culture cells. The expressed p41mapk was found to be localized in both the cytoplasmic and nuclear compartments of the cells. Significantly, the expression of p41mapk caused an increase in the phosphorylation of a nuclear substrate: Ser62 of c-Myc. Phosphorylation at Ser62 stimulated the activity of the NH2-terminal transactivation domain of c-Myc. Thus, p41mapk causes the phosphorylation and regulation of a physiologically significant nuclear target of signal transduction. These data establish that at least one MAP kinase isoform has a nuclear role during signal transduction.
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Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789
Prendergast, G. C., Lawe, D., & Ziff, E. B. (1991) · Cell · doi:10.1016/0092-8674(91)90457-a · Cited by 558
Cited by
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
Yang, S.-H., Galanis, A., & Sharrocks, A. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4028 · Cited by 244
Arnold, H. K., & Sears, R. C. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9128-9 · Cited by 111
Ganglioside GM3 inhibition of EGF receptor mediated signal transduction
Rebbaa, A., Hurh, J., Yamamoto, H., Kersey, D. S., & Bremer, E. G. (1996) · Glycobiology · doi:10.1093/glycob/6.4.399 · Cited by 83
Boros, J., O’Donnell, A., Donaldson, I. J., Kasza, A., Zeef, L., & Sharrocks, A. D. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp804 · Cited by 42
Molecular characterization of a zebrafish TCF ETS-domain transcription factor
Brown, L. A., Yang, S.-H., Hair, A., Galanis, A., & Sharrocks, A. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203197 · Cited by 10
Metadata
- Authors
- Seth, A., Gonzalez, F. A., Gupta, S., Raden, D. L., & Davis, R. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-12
- Volume
- 267
- Issue
- 34
- Pages
- 24796-24804
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1531194664
- Cited by
- 315
- References
- 3
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
