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Dominant negative MYC blocks transformation by ABL oncogenes

Sawyers, C. L., Callahan, W., & Witte, O. N. (1992) · Cell · doi:10.1016/0092-8674(92)90241-4 · Cited by 395 · see citing works

Structure and function of the b/HLH/Z domain of USF.

Ferré-D’Amaré, A. R., Pognonec, P., Roeder, R. G., & Burley, S. K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06247.x · Cited by 394 · see citing works

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

Sakamuro, D., Elliott, K. J., Wechsler-Reya, R., & Prendergast, G. C. (1996) · Nature Genetics · doi:10.1038/ng0996-69 · Cited by 387 · see citing works

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

Orian, A., van Steensel, B., Delrow, J. J., Bussemaker, H. J., Li, L., Sawado, T., Williams, E., Loo, L. W. M., Cowley, S. M., Yost, C., et al. (2003) · Genes & Development · doi:10.1101/gad.1066903 · Cited by 385 · see citing works

The c‐Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

Amati, B. B., Littlewood, T. D., Evan, G. I., & Land, H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06202.x · Cited by 384 · see citing works

Glycogen synthase kinase-3: functions in oncogenesis and development

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Function of the c-Myc Oncogenic Transcription Factor

Dang, C. V., Resar, L. M. S., Emison, E. S., Kim, S., Li, Q., Prescott, J. E., Wonsey, D. R., & Zeller, K. I. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4686 · Cited by 377 · see citing works

Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences

Blackwell, T. K., Huang, J., Ma, A. I., Kretzner, L., Alt, F. W., Eisenman, R. N., & Weintraub, H. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5216 · Cited by 377 · see citing works

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

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Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.Preprint

Stanton, B. R., Perkins, A. S., Tessarollo, L., Sassoon, D. A., & Parada, L. F. (1992) · Genes & Development · doi:10.1101/gad.6.12a.2235 · Cited by 369 · see citing works

Myc-binding-site recognition in the human genome is determined by chromatin context

Guccione, E., Martinato, F., Finocchiaro, G., Luzi, L., Tizzoni, L., Olio, V. D., Zardo, G., Nervi, C., Bernard, L., & Amati, B. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1434 · Cited by 365 · see citing works

c-Myc enhances protein synthesis and cell size during B lymphocyte development

Iritani, B. M., & Eisenman, R. N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13180 · Cited by 364 · see citing works

The role of c-myc in cell growth

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An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

Schreiber‐Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P. M., Skoultchi, A. I., & DePinho, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90356-9 · Cited by 361 · see citing works

An alternative pathway for gene regulation by Myc

Peukert, K., Staller, P., Schneider, A., Carmichael, G., Hänel, F., & Eilers, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5672 · Cited by 359 · see citing works

Myc—Max—Mad: a transcription factor network controlling cell cycle progression, differentiation and death

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The c-MYC Oncoprotein Is a Substrate of the Acetyltransferases hGCN5/PCAF and TIP60

Patel, J. H., Du, Y., Ard, P. G., Phillips, C., Carella, B. A., Chen, C., Rakowski, C., Chatterjee, C., Lieberman, P. M., Lane, W. S., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10826-10834.2004 · Cited by 354 · see citing works

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

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Mad3 and Mad4: novel Max‐interacting transcriptional repressors that suppress c‐myc dependent transformation and are expressed during neural and epidermal differentiation.

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Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

Pérez‐Roger, I., Kim, S., Griffiths, B. L., Sewing, A., & Land, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5310 · Cited by 327 · see citing works

Role of DNA methylation in the regulation of transcription

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Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells

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The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

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Signal transduction within the nucleus by mitogen-activated protein kinase.

Seth, A., Gonzalez, F. A., Gupta, S., Raden, D. L., & Davis, R. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35834-4 · Cited by 310 · see citing works

Differential modulation of cyclin gene expression by MYC.

Jansen‐Dürr, P., Meichle, A., Steiner, P., Pagano, M., Finke, K., Botz, J. W., Wessbecher, J., Draetta, G. F., & Eilers, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3685 · Cited by 310 · see citing works

Analysis of genomic targets reveals complex functions of MYC

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c‐Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

Li, L., Nerlov, C., Prendergast, G. C., MacGregor, D., & Ziff, E. B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06724.x · Cited by 306 · see citing works

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.Preprint

Ayer, D. E., & Eisenman, R. N. (1993) · Genes & Development · doi:10.1101/gad.7.11.2110 · Cited by 293 · see citing works

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

Bustelo, X. R., Ledbetter, J. A., & Barbacid, M. (1992) · Nature · doi:10.1038/356068a0 · Cited by 291 · see citing works

Reciprocal Regulation of Adipogenesis by Myc and C/EBPα

Freytag, S. O., & Geddes, T. J. (1992) · Science · doi:10.1126/science.256.5055.379 · Cited by 286 · see citing works

Myc target genes

Grandori, C. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01025-6 · Cited by 285 · see citing works

Max: functional domains and interaction with c-Myc.Preprint

Kato, G. J., Lee, W. M., Chen, L. L., & Dang, C. V. (1992) · Genes & Development · doi:10.1101/gad.6.1.81 · Cited by 276 · see citing works

Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

Shrivastava, A., Saleque, S., Kalpana, G. V., Artandi, S. E., Goff, S. P., & Calame, K. L. (1993) · Science · doi:10.1126/science.8266081 · Cited by 272 · see citing works

ChIP-nexus enables improved detection of in vivo transcription factor binding footprints

He, Q., Johnston, J., & Zeitlinger, J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3121 · Cited by 263 · see citing works

Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation.Preprint

Ohsako, S., Hyer, J., Panganiban, G. E. F., Oliver, I., & Caudy, M. A. (1994) · Genes & Development · doi:10.1101/gad.8.22.2743 · Cited by 253 · see citing works

c-Myc and apoptosis

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Repression of Cyclin D1: a Novel Function of MYC

Philipp, A., Schneider, A., Väsrik, I., Finke, K., Xiong, Y., Beach, D., Alitalo, K. K., & Eilers, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.4032 · Cited by 249 · see citing works

Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes.

Steiner, P., Philipp, A., Lukáš, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bártek, J., & Eilers, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00163.x · Cited by 246 · see citing works

Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.Preprint

Hurlin, P. J., Quéva, C., & Eisenman, R. N. (1997) · Genes & Development · doi:10.1101/gad.11.1.44 · Cited by 244 · see citing works

Mysterious liaisons: the relationship between c-Myc and the cell cycle

Obaya, Á. J., Mateyak, M. K., & Sedivy, J. M. (1999) · Oncogene · doi:10.1038/sj.onc.1202749 · Cited by 242 · see citing works

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

Roy, A. L., Carruthers, C. J. L., Gutjahr, T., & Roeder, R. G. (1993) · Nature · doi:10.1038/365359a0 · Cited by 242 · see citing works

Function and regulation of the transcription factors of the Myc/Max/Mad network

Lüscher, B. (2001) · Gene · doi:10.1016/s0378-1119(01)00697-7 · Cited by 238 · see citing works

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

Hammoudeh, D. I., Follis, A. V., Prochownik, E. V., & Metallo, S. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja900616b · Cited by 232 · see citing works

The p48 DNA‐binding subunit of transcription factor PTF1 is a new exocrine pancreas‐specific basic helix‐loop‐helix protein.

Krapp, A., Knöfler, M., Frutiger, S., Hughes, G. J., Hagenbüchle, O., & Wellauer, P. K. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00806.x · Cited by 230 · see citing works

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

Shibuyà, H., Yoneyama, M., Ninomiya‐Tsuji, J., Matsumoto, K., & Taniguchi, T. (1992) · Cell · doi:10.1016/0092-8674(92)90533-i · Cited by 229 · see citing works

A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.

Seth, A., Alvarez, E., Gupta, S., & Davis, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54312-x · Cited by 222 · see citing works

Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers.Preprint

Berberich, S. J., & Cole, M. D. (1992) · Genes & Development · doi:10.1101/gad.6.2.166 · Cited by 218 · see citing works

Consequences of heteromeric interactions among helix-loop-helix proteins.

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The basic region/helix – loop – helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation

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Myc‐Max heterodimers activate a DEAD box gene and interact with multiple E box‐related sites in vivo.

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DNA methylation inhibits elongation but not initiation of transcription in Neurospora crassaPreprint

Rountree, M. R., & Selker, E. U. (1997) · Genes & Development · doi:10.1101/gad.11.18.2383 · Cited by 207 · see citing works

Putative nuclear localization signals (NLS) in protein transcription factors

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Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse

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Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation

Kaluscha, S., Domcke, S., Wirbelauer, C., Stadler, M. B., Durdu, S., Burger, L., & Schübeler, D. (2022) · Nature Genetics · doi:10.1038/s41588-022-01241-6 · Cited by 202 · see citing works

Ca2 channel‐regulated neuronal gene expression

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Cross-talk between Site-specific Transcription Factors and DNA Methylation States

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Myc proteins as therapeutic targets

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Mutation of the MXI1 gene in prostate cancer

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Transcriptional activation by Myc is under negative control by the transcription factor AP‐2.

Gaubatz, S., Imhof, A., Dosch, R., Werner, O., Mitchell, P. J., Buettner, R., & Eilers, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07137.x · Cited by 197 · see citing works

Ligand-Dependent Recruitment of the Arnt Coregulator Determines DNA Recognition by the Dioxin Receptor

Whitelaw, M. L., Pongratz, I., Wilhelmsson, A., Gustafsson, J.-Å., & Poellinger, L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2504 · Cited by 191 · see citing works

Single amino acid substitutions alter helix‐loop‐helix protein specificity for bases flanking the core CANNTG motif.

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Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus

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Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancerPreprint

Taberlay, P. C., Statham, A. L., Kelly, T. K., Clark, S. J., & Jones, P. A. (2014) · Genome Research · doi:10.1101/gr.163485.113 · Cited by 183 · see citing works

A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.Preprint

Moens, C. B., Auerbach, A. B., Conlon, R. A., Joyner, A. L., & Rossant, J. (1992) · Genes & Development · doi:10.1101/gad.6.5.691 · Cited by 183 · see citing works

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

Prendergast, G. C., & Ziff, E. B. (1991) · Science · doi:10.1126/science.1987636 · Cited by 565 · see citing works

A new bind for Myc

Prendergast, G. C., & Ziff, E. B. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90196-b · Cited by 81 · see citing works

Methylation-sensitive DNA binding by v-myb and c-myb proteins.

Klempnauer, K.-H. (1993) · PubMed · Cited by 35 · see citing works

Identification of two novel mouse nuclear proteins that bind selectively to a methylated c-Myc recognizing sequence

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Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

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