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Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure.
Open accessAbstract
A cationic peptide, designated tachyplesin, was isolated from acid extracts of horseshoe crab (Tachypleus tridentatus) hemocyte debris. It consists of 17 residues and the structure determined by Edman degradation is: (formula; see text) The carboxyl-terminal end of this peptide was identified as arginine alpha-amide, and the whole sequence including the alpha-amide was also confirmed by fast atom bombardment mass spectrometry, indicating a mass value of 2263. Tachyplesin inhibits growth of both Gram-negative and -positive bacteria at low concentrations and formed a complex with bacterial lipopolysaccharide. Tachyplesin seems likely to act as antimicrobial peptide for self-defense in the horseshoe crab against invading microorganisms.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
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Destoumieux, D., Bulet, P., Loew, D., Van Dorsselaer, A., Rodriguez, J., & Bachère, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28398 · Cited by 441
Antimicrobial peptides in marine invertebrate health and disease
Destoumieux-Garzón, D., Rosa, R. D., Schmitt, P., Barreto, C., Vidal-Dupiol, J., Mitta, G., Gueguen, Y., & Bachère, E. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0300 · Cited by 160
Designed Antimicrobial Peptides for Recurrent Vulvovaginal Candidiasis Treatment
Woodburn, K. W., Clemens, L. E., Jaynes, J., Joubert, L.-M., Botha, A., Nazik, H., & Stevens, D. A. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02690-18 · Cited by 25
Metadata
- Authors
- Nakamura, T., Furunaka, H., Miyata, T., Tokunaga, F., Muta, T., Iwanaga, S., Niwa, M., Takao, T., & Shimonishi, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 263
- Issue
- 32
- Pages
- 16709-16713
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1483201238
- Cited by
- 531
- References
- 1
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nakamura, T., Furunaka, H., Miyata, T., Tokunaga, F., Muta, T., Iwanaga, S., Niwa, M., Takao, T., & Shimonishi, Y. (1988). Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)37448-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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