Designed Antimicrobial Peptides for Recurrent Vulvovaginal Candidiasis Treatment
Open accessAbstract
Recurrent vulvovaginal candidiasis (RVVC) is a widespread chronic infection that has a substantial negative impact on work and quality of life. The development of antimicrobial resistance and biofilm formation are speculated to contribute to Candida pathogenicity and treatment ineffectiveness. Designed antimicrobial peptides (dAMPs) are chemically modified from endogenous antimicrobial peptides that provide the first line of defense against pathogens.
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In a 2019 study, four dAMPs derived from tachyplesin I showed broad-spectrum antifungal activity against 46 clinical isolates, including fluconazole-sensitive and -resistant strains.
“These peptides showed broad-spectrum antifungal activity against 46 clinical isolates, including fluconazole-sensitive and -resistant strains of C. albicans, C. glabrata, C. tropicalis, and C. parapsilosis, as well as spontaneously resistant C. krusei [60].”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [60]
Vaginitis caused by strains other than C. albicans is more resistant to treatment.
“Vaginitis caused by strains other than C. albicans is more resistant to treatment [6,60].”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [60]
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- Authors
- Woodburn, K. W., Clemens, L. E., Jaynes, J., Joubert, L.-M., Botha, A., Nazik, H., & Stevens, D. A.
- Affiliations
- Riptide Bioscience, Inc., Vallejo, California, USA
- Tuskegee University (US)
- Stellenbosch University (ZA)
- California Institute for Medical Research (US)
- Corresponding author
- Woodburn, Kathryn W.
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2019-11
- Volume
- 63
- Issue
- 11
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC6811422
- OpenAlex
- W2969777679
- Cited by
- 25
- References
- 40
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SUNScholar (Stellenbosch University) (submittedVersion)
- Funders
- DOD | United States Army | MEDCOM | Congressionally Directed Medical Research Programs (JPC2 DM140274)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- recurrent vulvovaginal candidiasis, antimicrobial peptides, Candida albicans, biofilm formation, antimicrobial resistance, fungal infection treatment
- MeSH terms
- Animals, Antifungal Agents, Candida, Candidiasis, Vulvovaginal, Cell Survival, Female, Humans, Microbial Sensitivity Tests, Peptides, Keratinocytes, Fluconazole, Rats, Wistar, Biofilms, Antimicrobial Cationic Peptides, Drug Resistance, Fungal, Rats
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