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Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber.
Open accessAbstract
Spider dragline silk is a unique protein fiber possessing both high tensile strength and high elasticity. A partial cDNA clone for one dragline silk protein (Spidroin 1) was previously isolated. However, the predicted amino acid sequence could not account for the amino acid composition of dragline silk. We have isolated a partial cDNA clone for another dragline silk protein (Spidroin 2), demonstrating that dragline silk is composed of multiple proteins. The amino acid sequence exhibits an entirely different repetitive motif than Spidroin 1. Spidroin 2 is predicted to consist of linked beta-turns in proline-rich regions which alternate with beta-sheet regions composed of polyalanine segments. This structure for Spidroin 2 provides a model for dragline silk structure and function.
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Cited by
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
New Opportunities for an Ancient Material
Omenetto, F. G., & Kaplan, D. L. (2010) · Science · doi:10.1126/science.1188936 · Cited by 1,457
Xia, X.-X., Qian, Z.-G., Ki, C. S., Park, Y. H., Kaplan, D. L., & Lee, S. Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003366107 · Cited by 561
Decoding the secrets of spider silk
Eisoldt, L., Smith, A., & Scheibel, T. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70057-8 · Cited by 342
Metadata
- Authors
- Hinman, M. B., & Lewis, R. V.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 267
- Issue
- 27
- Pages
- 19320-19324
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1542008397
- Cited by
- 487
- References
- 0
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber. https://app.cochat.ai/papers/10.1016/s0021-9258(18)41777-2
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- Hinman, M. B., & Lewis, R. V. (1992). Isolation of a clone encoding a second dragline silk fibroin. Nephila clavipes dragline silk is a two-protein fiber. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)41777-2
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