The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family.
Open accessAbstract
We report cDNA cloning and primary structure of a new metalloproteinase inhibitor (ChIMP-3) produced by chicken embryo fibroblasts. ChIMP-3, formerly called the 21-kDa protein, is one of five ChIMPs (Chicken Inhibitor of MetalloProteinases). In this paper, we report that of the three most abundant ChIMPs, ChIMP-3 and ChIMP-a are extracellular matrix components, whereas ChIMP-2 is found in the media conditioned by the cells. Treatment of ChIMP-3 and ChIMP-a with N-glycosidase-F indicates that ChIMP-a is N-glycosylated whereas ChIMP-3 is not. The deduced amino acid sequence of ChIMP-3 predicts a protein whose properties are consistent with experimental measurements. Analysis of sequence alignments with the two previously described members of the TIMP (tissue inhibitor of metalloproteinases) family, TIMP-1 and TIMP-2, from various species indicates that ChIMP-3 is a related but distinct protein. This conclusion is supported by lack of significant binding with anti-TIMP-1 and anti-TIMP-2 antibodies. Based on these data, its unusual solubility properties, and its exclusive location in the matrix, we propose that ChIMP-3 is a new member of this family of metalloproteinase inhibitors, a TIMP-3.
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Cites
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Ovulation: Parallels With Inflammatory Processes
Duffy, D. M., Ko, C., Jo, M., Brannstrom, M., & Curry, T. E. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00075 · Cited by 513
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Metadata
- Authors
- Pavloff, N., Staskus, P. W., Kishnani, N. S., & Hawkes, S. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 267
- Issue
- 24
- Pages
- 17321-17326
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1549954866
- Cited by
- 271
- References
- 30
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family. https://app.cochat.ai/papers/10.1016/s0021-9258(18)41928-x
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- Pavloff, N., Staskus, P. W., Kishnani, N. S., & Hawkes, S. P. (1992). A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)41928-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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