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Fructose transporter in human spermatozoa and small intestine is GLUT5.
Open accessAbstract
We recently reported that the glucose transporter isoform, GLUT5, is expressed on the brush border membrane of human small intestinal enterocytes (Davidson, N. O., Hausman, A. M. L., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., and Bell, G. I. (1992) Am. J. Physiol. 262, C795-C800). To define its role in sugar transport, human GLUT5 was expressed in Xenopus oocytes and its substrate specificity and kinetic properties determined. GLUT5 exhibits selectivity for fructose transport, as determined by inhibition studies, with a Km of 6 mM. In addition, fructose transport by GLUT5 is not inhibited by cytochalasin B, a competitive inhibitor of facilitative glucose transporters. RNA and protein blotting studies showed the presence of high levels of GLUT5 mRNA and protein in human testis and spermatozoa, and immunocytochemical studies localize GLUT5 to the plasma membrane of mature spermatids and spermatozoa. The biochemical properties and tissue distribution of GLUT5 are consistent with a physiological role for this protein as a fructose transporter.
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Citations
Cited by
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
Macheda, M. L., Rogers, S., & Best, J. D. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20166 · Cited by 1,229
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
The glucose transporter family: structure, function and tissue-specific expression
Gould, G. W., & Holman, G. D. (1993) · Biochemical Journal · doi:10.1042/bj2950329 · Cited by 785
Physiology of Intestinal Absorption and Secretion
Kiela, P. R., & Ghishan, F. K. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.007 · Cited by 752
“Fructose is transported across the brush border membrane by a facilitated diffusion process via GLUT5 – also a member of the GLUT family of transporters [19].”
Background
Metadata
- Authors
- Burant, C. F., Takeda, J., Brot-Laroche, E., Bell, G. I., & Davidson, N. O.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 267
- Issue
- 21
- Pages
- 14523-14526
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1528581371
- Cited by
- 546
- References
- 0
- FWCI
- 24.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Fructose transporter in human spermatozoa and small intestine is GLUT5. https://app.cochat.ai/papers/10.1016/s0021-9258(18)42067-4
- The paper
- Burant, C. F., Takeda, J., Brot-Laroche, E., Bell, G. I., & Davidson, N. O. (1992). Fructose transporter in human spermatozoa and small intestine is GLUT5. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)42067-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
