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Stereoselective hydrolysis catalyzed by related beta-1,4-glucanases and beta-1,4-xylanases.
Open accessAbstract
Over 80 beta-1,4-glucanases and beta-1,4-xylanases can be classified into one of eight families on the basis of amino acid sequence similarities in their catalytic domains (Gilkes, N. R., Henrissat, B., Kilburn, D. G., Miller, R. C., Jr., and Warren, R. A. J. (1991) Microbiol. Rev. 55, 303-315). As a test of this classification, the stereochemical course of hydrolysis of 10 enzymes representative of five families has been determined using proton NMR. These data, together with published data for six additional enzymes, show that representatives of a given enzyme family have the same stereoselectivity: four families catalyze hydrolysis with retention of anomeric configuration, two with inversion. The results support the hypothesis that family members share a common general fold, active site topology, and catalytic mechanism.
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Cites
The relation between the divergence of sequence and structure in proteins.
Chothia, C., & Lesk, A. M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04288.x · Cited by 2,458
Cited by
New families in the classification of glycosyl hydrolases based on amino acid sequence similarities
Henrissat, B., & Bairoch, A. (1993) · Biochemical Journal · doi:10.1042/bj2930781 · Cited by 1,974
Substrate and Enzyme Characteristics that Limit Cellulose Hydrolysis
Mansfield, S. D., Mooney, C., & Saddler, J. N. (1999) · Biotechnology Progress · doi:10.1021/bp9900864 · Cited by 869
Payne, C. M., Knott, B. C., Mayes, H. B., Hansson, H., Himmel, M. E., Sandgren, M., Ståhlberg, J., & Beckham, G. T. (2015) · Chemical Reviews · doi:10.1021/cr500351c · Cited by 855
Metadata
- Authors
- Gebler, J., Gilkes, N. R., Claeyssens, M., Wilson, D. B., Béguin, P., Wakarchuk, W. W., Kilburn, D. G., Miller, R. C., Warren, R. A., & Withers, S. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-06
- Volume
- 267
- Issue
- 18
- Pages
- 12559-12561
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1574246355
- Cited by
- 213
- References
- 1
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Gebler, J., Gilkes, N. R., Claeyssens, M., Wilson, D. B., Béguin, P., Wakarchuk, W. W., Kilburn, D. G., Miller, R. C., Warren, R. A., & Withers, S. G. (1992). Stereoselective hydrolysis catalyzed by related beta-1,4-glucanases and beta-1,4-xylanases. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)42313-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
