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Sertoli cells synthesize and secrete transferrin-like protein.
Open accessAbstract
One of the major proteins secreted by Sertoli cells (Band 3) has a molecular weight on sodium dodecyl sulfate-polyacrylamide gels which corresponds to rat serum transferrin. The preparation of Sertoli cell-secreted proteins contains an iron-binding protein with electrophoretic properties on native polyacrylamide gels similar to serum transferrin. Antibodies against Sertoli cell-secreted proteins contain a component which will immunoprecipitate serum transferrin. Antibodies to serum transferrin cross-react with and immunoprecipitate a major component (Band 3) of [35S]-methionine-labeled Sertoli cell-secreted proteins. We propose that testicular transferrin is a major secretory product of Sertoli cells in culture. In addition to transferrin, antiserum to rat serum proteins will immunoprecipitate one other polypeptide from preparations of Sertoli cell-secreted proteins.
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Cited by
ORTH, J. M. (1984) · Endocrinology · doi:10.1210/endo-115-4-1248 · Cited by 326
The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
Kwok, J. C., & Richardson, D. R. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00213-x · Cited by 215
Metadata
- Authors
- Skinner, M. K., & Griswold, M. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-10
- Volume
- 255
- Issue
- 20
- Pages
- 9523-9525
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1522869477
- Cited by
- 356
- References
- 0
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Skinner, M. K., & Griswold, M. D. (1980). Sertoli cells synthesize and secrete transferrin-like protein. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)43419-9
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