The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
Abstract
For many years it has been known that neoplastic cells express high levels of the transferrin receptor 1 (TfR1) and internalize iron (Fe) from transferrin (Tf) at a tremendous rate. Considering the high requirement of neoplastic cells for Fe, understanding its metabolism is vital in terms of devising potential new therapies. Apart from TfR1, a number of molecules have been identified that may have roles in Fe metabolism and cellular proliferation. These molecules include transferrin (Tf), the oestrogen-inducible transferrin receptor-like protein, transferrin receptor 2 (TfR2), melanotransferrin (MTf), ceruloplasmin, and ferritin. In the present review these latter molecules are discussed in terms of their potential functions in tumour cell Fe metabolism and proliferation. Further studies are essential to determine the specific roles of these proteins in the pathogenesis of cancer.
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Malignant cancer phenotype is often associated with deregulated iron homeostasis, particularly expression of iron-regulated genes that fuel higher metabolic iron demands.
“The malignant cancer phenotype is often found in association with a deregulated iron homeostasis, particularly the expression of iron-regulated genes that fuel their higher metabolic iron demands needed for division, growth, and survival [10].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [10]
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- Authors
- Kwok, J. C., & Richardson, D. R.
- Affiliations
- The Heart Research Institute (AU)
- Corresponding author
- Richardson, Des R.
- ORCID
- Richardson, Des R.
- Venue
- Critical Reviews in Oncology/Hematology
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 42
- Issue
- 1
- Pages
- 65-78
- ISSN
- 1040-8428 (ISSN-L)
- OpenAlex
- W2049332203
- Cited by
- 215
- References
- 162
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 14 · 2023: 15 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 13 · 2014: 10 · 2013: 18 · 2012: 9
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Oncology/Hematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- iron metabolism, neoplastic cells, transferrin receptor 1, transferrin receptor 2, transferrin, melanotransferrin, ceruloplasmin, ferritin, tumor cell proliferation, carcinogenesis, iron transport
- MeSH terms
- Animals, Antigens, Neoplasm, Biological Transport, Cell Division, Ceruloplasmin, Endocytosis, Estrogens, Ferritins, Humans, Iron, Neoplasm Proteins, Neoplasms, Receptors, Transferrin, Transferrin, Nonheme Iron Proteins, Melanoma-Specific Antigens
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