Cited by 215Iron Metabolism and DisordersFerroptosis and cancer prognosisErythropoietin and Anemia Treatment

The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?

Kwok, Juliana C, Richardson, Des R.·2002·Critical Reviews in Oncology/Hematology

Abstract

For many years it has been known that neoplastic cells express high levels of the transferrin receptor 1 (TfR1) and internalize iron (Fe) from transferrin (Tf) at a tremendous rate. Considering the high requirement of neoplastic cells for Fe, understanding its metabolism is vital in terms of devising potential new therapies. Apart from TfR1, a number of molecules have been identified that may have roles in Fe metabolism and cellular proliferation. These molecules include transferrin (Tf), the oestrogen-inducible transferrin receptor-like protein, transferrin receptor 2 (TfR2), melanotransferrin (MTf), ceruloplasmin, and ferritin. In the present review these latter molecules are discussed in terms of their potential functions in tumour cell Fe metabolism and proliferation. Further studies are essential to determine the specific roles of these proteins in the pathogenesis of cancer.

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Crossref · 10.1016/s1040-8428(01)00213-x

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159 of 159 references verified0 citation errors · 0 not checkable

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  • Malignant cancer phenotype is often associated with deregulated iron homeostasis, particularly expression of iron-regulated genes that fuel higher metabolic iron demands.

    “The malignant cancer phenotype is often found in association with a deregulated iron homeostasis, particularly the expression of iron-regulated genes that fuel their higher metabolic iron demands needed for division, growth, and survival [10].”

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Authors
Kwok, J. C., & Richardson, D. R.
Affiliations
The Heart Research Institute (AU)
Corresponding author
Richardson, Des R.
Venue
Critical Reviews in Oncology/Hematology
Publisher
Elsevier BV
Published
2002-04
Volume
42
Issue
1
Pages
65-78
ISSN
1040-8428 (ISSN-L)
OpenAlex
W2049332203
Cited by
215
References
162
Citations by year
2026: 2 · 2025: 1 · 2024: 14 · 2023: 15 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 13 · 2014: 10 · 2013: 18 · 2012: 9
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Oncology/Hematology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Keywords
iron metabolism, neoplastic cells, transferrin receptor 1, transferrin receptor 2, transferrin, melanotransferrin, ceruloplasmin, ferritin, tumor cell proliferation, carcinogenesis, iron transport
MeSH terms
Animals, Antigens, Neoplasm, Biological Transport, Cell Division, Ceruloplasmin, Endocytosis, Estrogens, Ferritins, Humans, Iron, Neoplasm Proteins, Neoplasms, Receptors, Transferrin, Transferrin, Nonheme Iron Proteins, Melanoma-Specific Antigens

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