The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.
Open accessAbstract
The Escherichia coli and recombinant human cytosolic aconitases are inactivated by O2-., with a rate constant of approximately 3 x 10(7) M-1 s-1; the corresponding value for the porcine mitochondrial aconitase is approximately 0.8 x 10(7) M-1 s-1. Nitric oxide, which is reported to inactivate aconitase, did not do so at a perceptible rate, while incubation with peroxynitrite led to a rapid loss of aconitase activity. We propose that the reported inactivation of aconitase by nitric oxide in vivo is actually mediated through peroxynitrite, the product of the reaction between O2-. and NO..
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Ignarro, L. J., Fukuto, J. M., Griscavage, J. M., Rogers, N. E., & Byrns, R. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8103 · Cited by 856
Lowry, O. H., Carter, J., Ward, J. B., & Glaser, L. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34144-4 · Cited by 350
Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
Redox signaling: Nitrosylation and related target interactions of nitric oxide
Stamler, J. S. (1994) · Cell · doi:10.1016/0092-8674(94)90269-0 · Cited by 1,723
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292
Metadata
- Authors
- Hausladen, A., & Fridovich, I.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 269
- Issue
- 47
- Pages
- 29405-29408
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1509127316
- Cited by
- 585
- References
- 3
- FWCI
- 13.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hausladen, A., & Fridovich, I. (1994). Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)43893-8
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