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Cited by 1,292Iron Metabolism and DisordersTrace Elements in HealthNeurological diseases and metabolism

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

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Hentze, M W, Kühn, L C·1996·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.93.16.8175PMC PMC38642
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Abstract

As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular framework for the regulation of iron uptake, storage, and utilization has been defined. Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the expression of mRNAs that harbor IRP-binding sites, iron-responsive elements (IREs). Nitric oxide (NO) and oxidative stress in the form of H2O2 also signal to IRPs and thereby influence cellular iron metabolism. The recent discovery of two IRE-regulated mRNAs encoding enzymes of the mitochondrial citric acid cycle may represent the beginnings of elucidating regulatory coupling between iron and energy metabolism. In addition to providing insights into the regulation of iron metabolism and its connections with other cellular pathways, the IRE/IRP system has emerged as a prime example for the understanding of translational regulation and mRNA stability control. Finally, IRP-1 has highlighted an unexpected role for iron sulfur clusters as post-translational regulatory switches.

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Cited by

Sorted by citations

Authors
Hentze, M. W., & Kühn, L. C.
Affiliations
European Molecular Biology Laboratory (DE)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1996-08-06
Volume
93
Issue
16
Pages
8175-8182
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.93.16.8175
PMC
PMC38642
OpenAlex
W2099819774
Cited by
1,292
References
8
Citations by year
2026: 8 · 2025: 10 · 2024: 12 · 2023: 25 · 2022: 12 · 2021: 19 · 2020: 14 · 2019: 13 · 2018: 23 · 2017: 18 · 2016: 22 · 2015: 27 · 2014: 35 · 2013: 29 · 2012: 38
FWCI
43.68
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
iron metabolism, iron regulatory protein 1, IRP2, iron-responsive element, mRNA stability, translational regulation, nitric oxide, oxidative stress, hydrogen peroxide, iron absorption, iron storage, iron-sulfur clusters, energy metabolism
MeSH terms
Animals, Base Sequence, Binding Sites, Ferritins, Gene Expression Regulation, Homeostasis, Iron, Iron-Sulfur Proteins, Mitochondria, Molecular Sequence Data, Nitric Oxide, Nucleic Acid Conformation, Oxidation-Reduction, Receptors, Transferrin, Regulatory Sequences, Nucleic Acid, RNA Processing, Post-Transcriptional, RNA, Messenger, Protein Biosynthesis, RNA-Binding Proteins, Oxidative Stress, Iron-Regulatory Proteins, Iron Regulatory Protein 1, Iron Regulatory Protein 2

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