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Cited by 35Cytokine Signaling Pathways and Interactionsinterferon and immune responsesGenomics and Chromatin Dynamics

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Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes

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Harroch, S, Revel, M, Chebath, J·1994·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)47177-3
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Abstract

Interferons (IFNs), as well as some interleukins, growth factors, and hormones, all induce tyrosine phosphorylation of STAT1 and additional transcription factors of similar sizes. These factors are activated to translocate to nucleus and bind to enhancers of consensus sequence TTnCnnnAA (gamma-IFN activated sequence-like enhancers). In mammary cells or hybridoma B9 cells, four distinct tyrosine-phosphorylated transcription complexes activated by interleukin-6 (IL-6) and IFN-beta were observed: pIRFA and complexes I, II, and III (of increasing electrophoretic mobility). The factors have unequal affinities for enhancers of different genes; they are activated with distinct kinetics and to different extents by IL-6 and IFNs. The pIRFA band isolated from IL-6-stimulated B9 hybridoma cells revealed three DNA-interacting components: two large subunits of 91 and 98 kDa, as well as a small component of 46 kDa not seen in other complexes analyzed. One of the large pIRFA subunits may be APRF/STAT3, since pIRFA reacted with anti-APRF antibodies as do complexes I and II. However, pIRFA did not react with antibodies to STAT1, indicating STAT1 is not the other large component of pIRFA. Complex II, which reacted to anti-acute phase response factor antibodies also reacted to anti-STAT1 antibodies, whereas complex III reacted only to anti-STAT1 and was the only complex resistant to N-ethylmaleimide. By its multimeric subunit structure and its cytokine and enhancer sequence specificities, the s…

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Metadata

Authors
Harroch, S., Revel, M., & Chebath, J.
Affiliations
Weizmann Institute of Science (IL)
ORCID
Chebath, J
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1994-10
Volume
269
Issue
42
Pages
26191-26195
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)47177-3
OpenAlex
W1562490575
Cited by
35
References
37
Citations by year
2017: 2
FWCI
3.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
IL-6 signaling, STAT1, STAT3, interferon-beta, transcription factor complex, mammary cells, N-ethylmaleimide sensitivity, cytokine-induced gene expression
MeSH terms
alpha-Macroglobulins, Animals, Base Sequence, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Ethylmaleimide, Interferon-gamma, Molecular Sequence Data, Phosphoproteins, Phosphorylation, Rabbits, Transcription Factors, Tyrosine, Signal Transduction, Interleukin-6, Interferon Regulatory Factor-1

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