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Cited by 979Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and SignalingNF-κB Signaling Pathways

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

Stahl, Neil, Boulton, Teri G., Farruggella, Thomas, Ip, Nancy Y., Davis, Sam, Witthuhn, Bruce A., Quelle, Frederick W., Silvennoinen, Olli +4 more·1994·Science
DOI 10.1126/science.8272873
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Abstract

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

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Authors
Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J. N., & Yancopoulos, G. D.
Affiliations
  • Regeneron (United States) (US)
  • St. Jude Children's Research Hospital (US)
  • Inserm (FR)
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-01-07
Volume
263
Issue
5143
Pages
92-95
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8272873
OpenAlex
W2094111001
Cited by
979
References
0
Citations by year
2026: 11 · 2025: 16 · 2024: 16 · 2023: 13 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 13 · 2018: 13 · 2017: 11 · 2016: 22 · 2015: 16 · 2014: 19 · 2013: 14 · 2012: 15
FWCI
50.29
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
  • National Cancer Institute (P 30CA 21765, P30CA021765)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK42932, R01DK042932)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
ciliary neurotrophic factor, leukemia inhibitory factor, oncostatin M, interleukin-6, gp130, receptor dimerization, kinase phosphorylation, receptor interaction, cytokine signaling
MeSH terms
Animals, Cell Line, Enzyme Activation, Growth Inhibitors, Lymphokines, Membrane Glycoproteins, Nerve Tissue Proteins, Peptides, Phosphorylation, Protein-Tyrosine Kinases, Proteins, Proto-Oncogene Proteins, Tyrosine, Antigens, CD, Interleukin-6, Cytokines, Receptors, Growth Factor, Receptors, Cytokine, Receptors, Interleukin, Receptors, Interleukin-6, Receptor, Ciliary Neurotrophic Factor, Ciliary Neurotrophic Factor, Cytokine Receptor gp130, Leukemia Inhibitory Factor, Receptors, OSM-LIF, Janus Kinase 1, Janus Kinase 2, Receptors, Oncostatin M, Oncostatin M

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