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The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family.
Open accessAbstract
cDNA clones corresponding to the entire coding region of mature lipoprotein lipase were identified by antibody screening of a mouse macrophage library and sequenced. The predicted amino acid sequence indicates that the mature protein contains 447 amino acids with a molecular weight of 50,314. Comparison of the nucleotide and amino acid sequence with those of rat hepatic lipase and porcine pancreatic lipase reveals extensive homology among the enzymes, indicating that they are members of a gene family of lipases. Most striking is a conservation of five disulfide bridges in all three enzymes, strongly suggesting that the enzymes have similar overall folding patterns. Lipoprotein lipase is also shown to be extraordinarily conserved among mouse, human, and bovine species. The mRNA for lipoprotein lipase is abundant in heart and adipose tissue but is also present in a wide variety of other tissues. There are two major species of mRNA in mouse and human tissues examined, 3.6 and 3.4 kilobases (kb) in size. Rat tissues, on the other hand, contain only the 3.6-kb species while bovine tissues contain an additional 1.7-kb species.
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Cited by
Shimano, H., Shimomura, I., Hammer, R. E., Herz, J., Goldstein, J. L., Brown, M. S., & Horton, J. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119746 · Cited by 395
Human digestive and metabolic lipases—A brief review
Mukherjee, M. (2003) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/s1381-1177(03)00052-3 · Cited by 217
Convertible adipose tissue in mice.
Lončar, D. (1991) · Cell and Tissue Research · doi:10.1007/bf00678721 · Cited by 187
Takahashi, Y., & Ide, T. (2000) · British Journal of Nutrition · doi:10.1017/s0007114500001409 · Cited by 175
Semenkovich, C. F., Chen, S. H., Wims, M., Luo, C. C., Li, W. H., & Chan, L. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38369-3 · Cited by 160
Metadata
- Authors
- Kirchgessner, T. G., Svenson, K. L., Lusis, A. J., & Schotz, M. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-06
- Volume
- 262
- Issue
- 18
- Pages
- 8463-8466
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1485810221
- Cited by
- 297
- References
- 0
- FWCI
- 27.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kirchgessner, T. G., Svenson, K. L., Lusis, A. J., & Schotz, M. C. (1987). The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)47435-2
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