Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat
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We examined the effect of dietary fats rich inn-3 polyunsaturated fatty acids (PUFA) on mRNA levels in white and brown adipose tissues in rats. Four groups of rats were fed on a low-fat diet (20 g safflower oil/kg) or a high-fat diet (200 g/kg) containing safflower oil, which is rich inn-6 PUFA (linoleic acid), or perilla (α-linolenic acid) or fish oil (eicosapentaenoic and docosahexaenoic acids), both of which are rich inn-3 PUFA, for 21 d. Energy intake was higher in rats fed on a high-safflower-oil diet than in those fed on low-fat or high-fish-oil diet, but no other significant differences were detected among the groups. Perirenal white adipose tissue weight was higher and epididymal white adipose tissue weight tended to be higher in rats fed on a high-safflower-oil diet than in those fed on a low-fat diet. However, high-fat diets rich inn-3 PUFA, compared to a low-fat diet, did not increase the white adipose tissue mass. High-fat diets relative to a low-fat diet increased brown adipose tissue uncoupling protein 1 mRNA level. The increases were greater with fats rich inn-3 PUFA than withn-6 PUFA. A high-safflower-oil diet, compared to a low-fat diet, doubled the leptin mRNA level in white adipose tissue. However, high-fat diets rich inn-3 PUFA failed to increase it. Compared to a low-fat diet, high-fat diets down-regulated the glucose transporter 4 mRNA level in white adipose tissue. However, the decreases were attenuated with high-fat diets rich inn-3 PUFA. It is suggested that the alterations in gene expression in adipose tissue contribute to the physiological activities ofn-3 PUFA in preventing body fat accumulation and in regulating glucose metabolism in rats.
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PUFAs such as EPA and DHA stimulate UCP1 expression and adaptive non-shivering or diet-induced thermogenesis in brown adipocytes, as well as browning of WAT in C57BL/6 mice, Sprague-Dawley rats, and overweight humans.
“PUFAs such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also stimulate UCP1 expression and thus adaptive non-shivering or diet-induced thermogenesis in brown adipocytes, as well as the browning of the white adipose tissue (WAT) in C57BL/6 mice [67,68], Sprague-Dawley rats [69,70], and overweight humans [71].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [70]
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Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning
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Polysaccharides fromEnteromorpha proliferaImprove Glucose Metabolism in Diabetic Rats
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Dietary Fat Influences the Expression of Contractile and Metabolic Genes in Rat Skeletal Muscle
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Omega 3 polyunsaturated fatty acids and body weight
Martínez‐Victoria, E., & Yago, M. D. (2012) · British Journal Of Nutrition · doi:10.1017/s000711451200150x · Cited by 54 · see citing works
Plausible mechanisms for effects of long-chain polyunsaturated fatty acids on growth
Lapillonne, A., Clarke, S. D., & Heird, W. C. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00397-4 · Cited by 54 · see citing works
The effect of six different C18 fatty acids on body fat and energy metabolism in mice
Javadi, M., Everts, H., Hovenier, R., Kocsis, S., Lankhorst, A., Lemmens, A. G., Schonewille, J. T., Terpstra, A. H. M., & Beynen, A. C. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041217 · Cited by 51 · see citing works
Browning of Adipocytes: A Potential Therapeutic Approach to Obesity
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Leptin and the control of obesity
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Leptin regulation of lipid homeostasis: dietary and metabolic implications
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Nutritional and non-nutritional agents that stimulate white adipose tissue browning
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Monk, J. M., Liddle, D. M., Hutchinson, A. L., Wu, W., Lepp, D., David, W. L., Robinson, L. E., & Power, K. A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.07.007 · Cited by 39 · see citing works
Jang, I.-S., Hwang, D. Y., Chae, K. R., Lee, J. E., Kim, Y. K., Kang, T. S., Hwang, J. H., Lim, C. H., & Huh, Y. B. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002801 · Cited by 39 · see citing works
A review on differential effects of dietary fatty acids on weight, appetite and energy expenditure
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Greasing the wheels of managing overweight and obesity with omega-3 fatty acids
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Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation
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Recent highly cited articles in theBritish Journal of Nutrition
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Fish oil as a potential activator of brown and beige fat thermogenesis
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Chia oil induces browning of white adipose tissue in high-fat diet-induced obese mice
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- Authors
- Takahashi, Y., & Ide, T.
- Affiliations
- Ministry of Agriculture, Forestry and Fisheries (JP)
- Corresponding author
- Ide, Takashi
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2000-08
- Volume
- 84
- Issue
- 2
- Pages
- 175-184
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2166122956
- Cited by
- 175
- References
- 50
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 7
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- omega-3 fatty acids, brown adipose tissue, white adipose tissue, UCP1, leptin, glucose transporter 4, perilla oil, fish oil, safflower oil, dietary fat, adipose tissue gene expression, body fat accumulation, glucose metabolism, energy intake
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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