Persistent oxidative stress in cancer

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816 · see citing works

Production of large amounts of hydrogen peroxide by human tumor cells.

Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,504 · see citing works

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224 · see citing works

Robbins pathologic basis of disease

Cotran, R. S., Kumar, V., & Collins, T. (1989) · Medical Entomology and Zoology · Cited by 1,944 · see citing works

Free radicals, antioxidant enzymes, and carcinogenesis

Sun, Y. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90156-d · Cited by 1,067 · see citing works

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

Kasai, H., & Nishimura, S. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.4.2137 · Cited by 948 · see citing works

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

Matthews, J. R., Wakasugi, N., Virelizier, J., Yodoi, J., & Hay, R. T. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.15.3821 · Cited by 831 · see citing works

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

Batist, G., Tulpule, A., Sinha, B. K., Katki, A. G., Myers, C. E., & Cowan, K. H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66748-1 · Cited by 790 · see citing works

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

Kuchino, Y., Mori, F., Kasai, H., Inoue, H., Iwai, S., Miura, K., Ohtsuka, E., & Nishimura, S. (1987) · Nature · doi:10.1038/327077a0 · Cited by 770 · see citing works

The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center.

Johnson, D., & Travis, J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50689-x · Cited by 466 · see citing works

Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction

Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300 · see citing works

Transcriptional activation of early‐response genes by hydrogen peroxide in a mouse osteoblastic cell line

Nose, K., Shibanuma, M., Kikuchi, K., et al. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16261.x · Cited by 291 · see citing works

DNA base modifications in chromatin of human cancerous tissues

Oliński, R., Zastawny, T. H., Budzbon, J., Skokowski, J., Zegarski, W., & Dizdaroğlu, M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81093-2 · Cited by 284 · see citing works

DNA and Free Radicals

Aruoma, O. I., Halliwell, B. B., & DPhil, B. H. (1993) · Medical Entomology and Zoology · Cited by 283 · see citing works

Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis.

Shimoda, R., Nagashima, M., Sakamoto, M., Yamaguchi, N., Hirohashi, S., Yokota, J., & Kasai, H. (1994) · PubMed · Cited by 279 · see citing works

Major alterations in the nucleotide structure of DNA in cancer of the female breast.

Malins, D. C., & Haimanot, R. (1991) · PubMed · Cited by 267 · see citing works

Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer

Jaruga, P., Zastawny, T. H., Skokowski, J., Dizdaroğlu, M., & Oliński, R. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80240-8 · Cited by 242 · see citing works

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids

Gutteridge, J. M. C., Rowley, D. A., & Halliwell, B. B. (1982) · Biochemical Journal · doi:10.1042/bj2060605 · Cited by 217 · see citing works

Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.

Nakagawa, K., Saijo, N., Tsuchida, S., Sakai, M., Tsunokawa, Y., Yokota, J., Muramatsu, M., Sato, K., Terada, M., & Tew, K. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39562-6 · Cited by 197 · see citing works

Glutathione levels and variability in breast tumors and normal tissue

Perry, R. R., Mazetta, J., Levin, M., & BARRANCO, S. C. (1993) · Cancer · doi:10.1002/1097-0142(19930801)72:3 · Cited by 190 · see citing works

Formation of 8‐hydroxy‐2′‐deoxyguanosine and 4‐hydroxy‐2‐nonenal‐modified proteins in human renal‐cell carcinoma

Okamoto, K., Toyokuni, S., Uchida, K., Ogawa, O., Takenewa, J., Kakehi, Y., Kinoshita, H., Hattori‐Nakakuki, Y., Hiai, H., & Yoshida, O. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910580613 · Cited by 179 · see citing works

Reactive oxygen-reducing and protein-refolding activities of adult t cell leukemia-derived factor /human thioredoxin

Mitsui, A., Hírakawa, T., & Yodoi, J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81536-0 · Cited by 176 · see citing works

DNA base modifications in renal chromatin of wistar rats treated with a renal carcinogen, ferric nitrilotriacetate

Toyokuni, S., Mori, T., & Dizdaroğlu, M. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570122 · Cited by 175 · see citing works

Immunohistochemical detection of the placental form of glutathione S-transferase in dysplastic and neoplastic human uterine cervix lesions.

Shiratori, Y., Soma, Y., Maruyama, H., et al. (1987) · PubMed · Cited by 127 · see citing works

Negative regulation of catalase gene expression in hepatoma cells.

Sato, K., Ito, K., Kohara, H., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2525 · Cited by 123 · see citing works

Elevation of the placental glutathione S-transferase form (GST-pi) in tumor tissues and the levels in sera of patients with cancer.

Tsuchida, S., Sekine, Y., Shineha, R., et al. (1989) · PubMed · Cited by 103 · see citing works

REVIEW: Methionine Sulfoxide and the Oxidative Regulation of Plasma Proteinase Inhibitors

Swaim, M. W., & Pizzo, S. V. (1988) · Journal of Leukocyte Biology · doi:10.1002/jlb.43.4.365 · Cited by 95 · see citing works

Chemotherapy of renal cell carcinoma: 1983-1989.

Yagoda, A. (1989) · PubMed · Cited by 92 · see citing works

Robbins' Pathologic Basis of Disease

Anthony, P. (1990) · Journal of Clinical Pathology · doi:10.1136/jcp.43.2.176-a · Cited by 88 · see citing works

Mesenteric infarction secondary to tumor emboli from primary aortic sarcoma. Guidelines for diagnosis and management

Higgins, R., Posner, M. C., Moosa, H. H., Staley, C. A., Pataki, K. I., & Mendelow, H. (1991) · Cancer · doi:10.1002/1097-0142(19911001)68:7 · Cited by 86 · see citing works

Resistance of human tumor cells in vitro to oxidative cytolysis.

O’Donnell-Tormey, J., DeBoer, C. J., & Nathan, C. F. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111981 · Cited by 61 · see citing works

The incidence of pediatric cancer in Florida, 1981 to 1986

Roush, S. W., Krischer, J. P., Pollock, N. C., Cox, M. W., Pollock, B. H., & Buyer, J. (1992) · Cancer · doi:10.1002/1097-0142(19920415)69:8 · Cited by 9 · see citing works

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452 · see citing works

Oxidative DNA damage: mechanisms, mutation, and disease

Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works

Oxidative stress and cancer: Have we moved forward?

Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302 · see citing works

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works

Why Nature Chose Selenium

Reich, H. J., & Hondal, R. J. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00031 · Cited by 923 · see citing works

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

Liu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.002 · Cited by 697 · see citing works

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · see citing works

Role of iron in carcinogenesis: cancer as a ferrotoxic disease

Toyokuni, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2008.01001.x · Cited by 552 · see citing works

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

Wondrak, G. T. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2541 · Cited by 462 · see citing works

Prooxidant Actions of Carotenoids in Biologic Systems

Palozza, P. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01762.x · Cited by 328 · see citing works

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

Chen, X., Song, M., Zhang, B., & Zhang, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1580967 · Cited by 326 · see citing works

Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress

Yamaguchi, K., Mandai, M., Toyokuni, S., Hamanishi, J., Higuchi, T., Takakura, K., & Fujii, S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1614 · Cited by 324 · see citing works

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320 · see citing works

Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis

Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.024 · Cited by 252 · see citing works

B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis

Muri, J., Thut, H., Bornkamm, G. W., & Kopf, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.070 · Cited by 198 · see citing works

Oxidative and antioxidative mechanisms in oral cancer and precancer: A review

Choudhari, S. K., Chaudhary, M., Gadbail, A. R., Sharma, A., & Tekade, S. (2014) · Oral Oncology · doi:10.1016/j.oraloncology.2013.09.011 · Cited by 177 · see citing works

Cellular aspects of photocarcinogenesis

Nishigori, C. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b507471a · Cited by 161 · see citing works

Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine

Datta, K., Suman, S., Kallakury, B. V. S., & Fornace, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042224 · Cited by 175 · see citing works

Ferroptosis at the crossroads of infection, aging and cancer

Toyokuni, S., Yanatori, I., Kong, Y., Zheng, H., Motooka, Y., & Jiang, L. (2020) · Cancer Science · doi:10.1111/cas.14496 · Cited by 142 · see citing works

Aberrant redox regulation in human metastatic melanoma cells compared to normal melanocytes

Meyskens, F. L., McNulty, S. E., Buckmeier, J. A., Tohidian, N. B., Spillane, T. J., Kahlon, R. S., & Gonzalez, R. I. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00650-5 · Cited by 126 · see citing works

The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy

Policastro, L. L., Ibañez, I. L., Notcovich, C., Duran, H. A., & Podhajcer, O. L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4367 · Cited by 120 · see citing works

The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Toyokuni, S. (2016) · Pathology International · doi:10.1111/pin.12396 · Cited by 111 · see citing works

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

Toyokuni, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.401 · Cited by 102 · see citing works

The role of ultraviolet radiation in melanomagenesis

Von Thaler, A., Kamenisch, Y., & Berneburg, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.01025.x · Cited by 100 · see citing works

Oxidative stress as an iceberg in carcinogenesis and cancer biology

Toyokuni, S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.025 · Cited by 66 · see citing works

Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic Agents

Pahl, P. M. B., & Horwitz, L. D. (2005) · Cancer Investigation · doi:10.1080/07357900500359976 · Cited by 40 · see citing works

Analysis of Hexanal and Heptanal in Human Blood by Simultaneous Derivatization and Dispersive Liquid–Liquid Microextraction then LC–APCI–MS–MS

Xu, H., Song, D., Cui, Y., Hu, S., Yu, Q.-W., & Feng, Y.-Q. (2009) · Chromatographia · doi:10.1365/s10337-009-1208-7 · Cited by 37 · see citing works

Genomic Instability: DNA Repair and Cancer

Carlos, A. R. (2019) · Learning materials in biosciences · doi:10.1007/978-3-030-11812-9_5

RADIATION-INDUCED GENOMIC INSTABILITY: RADIATION QUALITY AND DOSE RESPONSE

Smith, L. E., Nagar, S., Kim, G. J., & Morgan, W. F. (2003) · Health Physics · doi:10.1097/00004032-200307000-00006 · Cited by 128 · see citing works

DNA damage in cells exhibiting radiation-induced genomic instability

Keszenman, D. J., Kolodiuk, L., & Baulch, J. E. (2015) · Mutagenesis · doi:10.1093/mutage/gev006 · Cited by 13 · see citing works

DNA Damage in Cancer Therapeutics: A Boon or a Curse?

Khanna, A. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3247 · Cited by 140 · see citing works

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan

Sebastian, R., & Raghavan, S. C. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw081 · Cited by 55 · see citing works