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Cited by 342Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Human plasma phospholipid transfer protein causes high density lipoprotein conversion.

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Jauhiainen, M., Metso, J., Pahlman, R., Blomqvist, S., van Tol, A., Ehnholm, C.·1993·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)53575-4
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Abstract

The effect of human plasma phospholipid transfer protein (PLTP) on the particle size distribution of human high density lipoprotein (HDL) was studied by incubating human HDL3 (particle diameter, 8.7 nm) together with PLTP in vitro. Incubation of HDL3 with highly purified preparations of PLTP, devoid of cholesterol ester transfer protein (CETP), induced a conversion of the homogenous population of HDL particles into two main populations of particles, one larger, particle diameter 10.9 nm, and one smaller, particle diameter 7.8 nm, than the original HDL3. These size changes were evident as analyzed by gradient gel electrophoresis and by high resolution gel filtration. The degree of the conversion was dependent on the amount of PLTP added to the incubation and on incubation time. An inhibitory monoclonal antibody (TP-1) directed against CETP had no effect on the HDL conversion. The PLTP used was purified to homogeneity from human plasma using ultracentrifugation and a combination of hydrophobic, cation-exchange, heparin-Sepharose-, anion-exchange, and gel filtration chromatographies. The monoclonal anti-CETP antibody (TP-1), which inhibits lipid transfer catalyzed by CETP, did not react with PLTP or inhibit its activity. The estimated molecular weight of PLTP is 75,000. The present study demonstrates that PLTP can act like the putative conversion factor and has the ability to convert HDL3 into populations of larger and smaller HDL particles. The mechanism(s) involved in this process and its physiological relevance remain to be established.

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Crossref · 10.1016/s0021-9258(18)53575-4

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Research works printed but not linked: 1

  1. Nishida, 1992, FASEB J., 6, 2136

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Metadata

Authors
Jauhiainen, M., Metso, J., Pahlman, R., Blomqvist, S., van Tol, A., & Ehnholm, C.
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1993-02
Volume
268
Issue
6
Pages
4032-4036
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)53575-4
OpenAlex
W1577273492
Cited by
342
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 10 · 2012: 9
FWCI
16.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
phospholipid transfer protein, high-density lipoprotein, HDL3, cholesteryl ester transfer protein, lipid transfer, protein purification, molecular weight determination
MeSH terms
Carrier Proteins, Cholesterol Esters, Chromatography, Liquid, Glycoproteins, Humans, Lipoproteins, HDL, Membrane Proteins, Particle Size, Phospholipids, Phospholipid Transfer Proteins, Cholesterol Ester Transfer Proteins

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