Cited by 342Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Human plasma phospholipid transfer protein causes high density lipoprotein conversion.

Open access

Jauhiainen, M., Metso, J., Pahlman, R., Blomqvist, S., van Tol, A., Ehnholm, C.·1993·Journal of Biological Chemistry

Open this paper in CoChat — free account

Abstract

The effect of human plasma phospholipid transfer protein (PLTP) on the particle size distribution of human high density lipoprotein (HDL) was studied by incubating human HDL3 (particle diameter, 8.7 nm) together with PLTP in vitro. Incubation of HDL3 with highly purified preparations of PLTP, devoid of cholesterol ester transfer protein (CETP), induced a conversion of the homogenous population of HDL particles into two main populations of particles, one larger, particle diameter 10.9 nm, and one smaller, particle diameter 7.8 nm, than the original HDL3. These size changes were evident as analyzed by gradient gel electrophoresis and by high resolution gel filtration. The degree of the conversion was dependent on the amount of PLTP added to the incubation and on incubation time. An inhibitory monoclonal antibody (TP-1) directed against CETP had no effect on the HDL conversion. The PLTP used was purified to homogeneity from human plasma using ultracentrifugation and a combination of hydrophobic, cation-exchange, heparin-Sepharose-, anion-exchange, and gel filtration chromatographies. The monoclonal anti-CETP antibody (TP-1), which inhibits lipid transfer catalyzed by CETP, did not react with PLTP or inhibit its activity. The estimated molecular weight of PLTP is 75,000. The present study demonstrates that PLTP can act like the putative conversion factor and has the ability to convert HDL3 into populations of larger and smaller HDL particles. The mechanism(s) involved in this process and its physiological relevance remain to be established.

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)53575-4

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218
THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM
Havel, R. J., Eder, H. A., & Bragdon, J. H. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103182 · Cited by 8,737
Methods of enzymatic analysis
(1985) · International Journal of Biochemistry · doi:10.1016/0020-711x(85)90098-9 · Cited by 3,494
PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE
Miller, G. J., & Miller, N. E. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92376-4 · Cited by 2,621
The plasma lecithin:cholesterol acyltransferase reaction
Glomset, J. A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43114-1 · Cited by 2,396
High density lipoprotein metabolism.
Eisenberg, S. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37713-0 · Cited by 1,212
High density lipoprotein cholesterol and mortality. The Framingham Heart Study.
Wilson, P. W. F., Abbott, R. D., & Castelli, W. P. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.6.737 · Cited by 644
Early incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein
Castro, G. R., & Fielding, C. J. (1988) · Biochemistry · doi:10.1021/bi00401a005 · Cited by 641
Characterization of human high-density lipoproteins by gradient gel electrophoresis
Blanche, P. J., Gong, E. L., Forte, T. M., & Nichols, A. V. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90253-8 · Cited by 614
Formation of high density lipoprotein2-like particles during lipolysis of very low density lipoproteins in vitro.
Patsch, J. R., Gotto, A. M., Olivercrona, T., & Eisenberg, S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4519 · Cited by 509
Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A-I and A-II and particles containing A-I but no A-II.
Cheung, M. C., & Albers, J. J. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71339-6 · Cited by 473
Hydrolysis of human plasma high density lipoprotein2-phospholipids and triglycerides by hepatic lipase
Shirai, K., Barnhart, R. L., & Jackson, R. L. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(81)80217-3 · Cited by 205
Immunoturbidimetric determination of apolipoproteins A-1 and B in serum
Riepponen, P., Marniemi, J., & Rautaoja, T. (1987) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365518709168939 · Cited by 198
Separation of a plasma phospholipid transfer protein from cholesterol ester/phospholipid exchange protein.
Tall, A. R., Abreu, E., & Shuman, J. D. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32904-1 · Cited by 194
Subpopulations of apolipoprotein A-I in human high-density lipoproteins their metabolic properties and response to drug therapy
Atmeh, R. F., Shepherd, J., & Packard, C. J. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90172-8 · Cited by 181
Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma.
Tollefson, J. H., Ravnik, S. E., & Albers, J. J. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38404-2 · Cited by 180
Immunoturbidimetric determination of apolipoproteins A-1 and B in serum
Riepponen, P., Marniemi, J., & Rautaoja, T. (1987) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518709168939 · Cited by 172
Improved estimation of cholesteryl ester transfer/exchange activity in serum or plasma.
Groener, J. E., Pelton, R. W., & Kostner, G. M. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.2.283 · Cited by 162
Transfer of [14C]phosphatidylcholine between liposomes and human plasma high density lipoprotein Partial purification of a transfer-stimulating plasma factor using a rapid transfer assay
Damen, J., Regts, J., & Scherphof, G. L. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90271-5 · Cited by 155
Different locations of cholesteryl ester transfer protein and phospholipid transfer protein activities in plasma
Speijer, H., Groener, J. E. M., VANRAMSHORST, E., & Vantol, A. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90110-o · Cited by 149
Self-citation
Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins.
Hopkins, G. J., & Barter, P. J. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38740-x · Cited by 103
Characterization of high density lipoprotein subspecies: structural studies by single vertical spin ultracentrifugation and immunoaffinity chromatography
Cheung, M. C., Segrest, J. P., Albers, J. J., Cone, J. T., Brouillette, C. G., Chung, B. H., Kashyap, M. L., Glasscock, M. A., & Anantharamaiah, G. M. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38631-4 · Cited by 103
Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-.beta.-high-density lipoprotein pathway
Hitoshi, H., & Yokoyama, S. (1992) · Biochemistry · doi:10.1021/bi00122a021 · Cited by 94
Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody. Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma.
Yen, F. T., Deckelbaum, R. J., Mann, C. J., Marcel, Y. L., Milne, R. W., & Tall, A. R. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114112 · Cited by 84
Role of lipid transfers in the formation of a subpopulation of small high density lipoproteins.
Hopkins, G. J., Chang, L. B., & Barter, P. J. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34392-3 · Cited by 82
Simultaneous transfer of cholesteryl ester and phospholipid by protein(s) isolated from human lipoprotein-free plasma
Ihm, J., Harmony, J. A. K., Ellsworth, J. L., & Jackson, R. L. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)90604-x · Cited by 79
High density lipoproteins
Avogaro, P., Cazzolato, G., Bittolo-Bon, G., & Belussi, F. (1982) · La Ricerca in Clinica e in Laboratorio · doi:10.1007/bf02909312 · Cited by 73
Molecular pathways in the transformation of model discoidal lipoprotein complexes induced by lecithin: Cholesterol acyltransferase
Nichols, A. V., Blanche, P. J., Gong, E. L., Shore, V. G., & Forte, T. M. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90001-3 · Cited by 70
Isolation of a high-density-lipoprotein conversion factor from human plasma. A possible role of apolipoprotein A-IV as its activator
Barter, P. J., Rajaram, O. V., Chang, L., Rye, K., Gambert, P., Lagrost, L., Ehnholm, C., & Fidge, N. (1988) · Biochemical Journal · doi:10.1042/bj2540179 · Cited by 67
Self-citation
Alterations of HDL cholesterol distribution induced by incubation of human serum
Gambert, P., Lallemant, C., Athias, A., & Padieu, P. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90159-x · Cited by 65
Role of cholesteryl ester transfer protein (CETP) in the HDL conversion process as evidenced by using anti-CETP monoclonal antibodies
Lagrost, L., Gambert, P., Guyard‐Dangremont, V., Athias, A., & Lallemant, C. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42341-7 · Cited by 63
Changes in the size and density of human high-density lipoproteins promoted by a plasma-conversion factor
Rye, K., & Barter, P. J. (1986) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(86)90062-7 · Cited by 61
Facilitation of phosphatidylcholine transfer into high density lipoproteins by an apolipoprotein in the density 1.20-1.26 g/ml fraction of plasma
Tall, A. R., Forester, L. R., & Bongiovanni, G. L. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37996-7 · Cited by 61
Chromatofocusing of human high density lipoproteins and isolation of lipoproteins A and A-I
Nestruck, A. C., Niedmann, P. D., Wieland, H., & Seidel, D. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90099-1 · Cited by 59
Changes in the size of reconstituted high density lipoproteins during incubation with cholesteryl ester transfer protein: the role of apolipoproteins.
Rye, K.-A., Garrety, K., & Barter, P. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41541-x · Cited by 57
The interaction of cholesteryl ester transfer protein and unesterified fatty acids promotes a reduction in the particle size of high-density lipoproteins
Barter, P. J., Chang, L., Newnham, H. H., Rye, K., & Rajaram, O. V. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90206-d · Cited by 56
In vitro modulation of the distribution of normal human plasma high density lipoprotein subfractions through the lecithin: Cholesterol acyltransferase reaction
Daerr, W. H., & Greten, H. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90142-4 · Cited by 53
Lipid transfers between reconstituted high density lipoprotein complexes and low density lipoproteins: effects of plasma protein factors
Jonas, A., Kézdy, K. E., Williams, M., & Rye, K.-A. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38436-4 · Cited by 46
Rapid purification of human plasma lipid transfer proteins.
Ohnishi, T., Yokoyama, S., & Yamamoto, A. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43162-1 · Cited by 44
Fluorescence assay of the specificity of human plasma and bovine liver phospholipid transfer proteins
Massey, J. B., Hickson-Bick, D. L. M., Via, D. P., Gotto, A. M., & Pownall, H. J. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90038-4 · Cited by 43
Increases in the particle size of high-density lipoproteins induced by purified lecithin: cholesterol acyltransferase: effect of low-density lipoproteins
Rajaram, O. V., & Barter, P. J. (1986) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(86)90206-7 · Cited by 34
Interaction of the high density lipoprotein conversion factor with recombinant discoidal complexes of egg phosphatidylcholine, free cholesterol, and apolipoprotein A-I.
Rye, K. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38362-0 · Cited by 29
Evidence of the existence of a high-density lipoprotein transformation factor in pig and rabbit plasma
Rye, K.-A., & Barter, P. J. (1984) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(84)90070-5 · Cited by 24
Substrate specificity of human plasma phospholipid transfer protein
Sweeny, S. A., & Jonas, A. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90283-8 · Cited by 22
Apolipoprotein A-II modulates HDL remodeling in plasma
Calabresi, L., Banfi, C., Sirtori, C. R., & Franceschini, G. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90098-g · Cited by 20
Effect of the human cholesteryl ester transfer protein on the particle size redistribution of specific subpopulations of high density lipoproteins-3
Lagrost, L. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90284-3 · Cited by 10

Research works printed but not linked: 1

Nishida, 1992, FASEB J., 6, 2136

Sorted by citations

Plasma cholesteryl ester transfer protein
Tall, A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36957-1 · Cited by 953
ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease
Oram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 531
Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL
Zannis, V. I., Chroni, A., & Krieger, M. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0030-4 · Cited by 404
Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects
Aro, A., Jauhiainen, M., Partanen, R., Salminen, I., & Mutanen, M. L. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1419 · Cited by 281
Self-citation
Alterations in high‐density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins
Borggreve, S. E., Vries, R. D., & Dullaart, R. P. F. (2003) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2003.01263.x · Cited by 277

See all 342

Authors: Jauhiainen, M., Metso, J., Pahlman, R., Blomqvist, S., van Tol, A., & Ehnholm, C.
ORCID: Jauhiainen, M.
Blomqvist, S.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1993-02
Volume: 268
Issue: 6
Pages: 4032-4036
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)53575-4
OpenAlex: W1577273492
Cited by: 342
References: 48
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 10 · 2012: 9
FWCI: 16.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10117 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: phospholipid transfer protein, high-density lipoprotein, HDL3, cholesteryl ester transfer protein, lipid transfer, protein purification, molecular weight determination
MeSH terms: Carrier Proteins, Cholesterol Esters, Chromatography, Liquid, Glycoproteins, Humans, Lipoproteins, HDL, Membrane Proteins, Particle Size, Phospholipids, Phospholipid Transfer Proteins, Cholesterol Ester Transfer Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human plasma phospholipid transfer protein causes high density lipoprotein conversion.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks