The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria.
Open accessAbstract
The role of the Na(+)-Ca2+ exchanger of heart mitochondria in cellular functioning is not yet clear. The objectives of this study were to investigate the effects of stimulation and inhibition of the Na(+)-Ca2+ exchanger on the matrix free Ca2+ concentration in isolated heart mitochondria and to determine the consequences of these changes on the rate of NADH production via Krebs cycle turnover and the oxidative phosphorylation rate (OPR) supported by alpha-ketoglutarate dehydrogenase, a Ca(2+)-regulated matrix enzyme. Activation of Na(+)-Ca2+ exchange by increasing extramitochondrial Na+ concentration was found to decrease the matrix free [Ca2+] in a concentration-dependent manner. Inhibitors of mitochondrial Na(+)-Ca2+ exchange activity inhibited the decrease in matrix free [Ca2+] mediated by Na+. Increasing concentrations of Na+ were also found to inhibit both the rate of NADH production and OPR. Inhibitors of mitochondrial Na(+)-Ca2+ exchange also blocked the effects of Na+ on the rate of NADH production and OPR in a similar concentration range. The results indicate that alterations in matrix free [Ca2+] induced by changes in mitochondrial Na(+)-Ca2+ exchange activity are translated into changes in the rate of NADH production and the overall rate of oxidative phosphorylation.
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Cites
Mechanisms by which mitochondria transport calcium
Gunter, T. E., & Pfeiffer, D. R. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c755 · Cited by 1,640
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
McCormack, J. G., Halestrap, A. P., & Denton, R. M. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.391 · Cited by 1,398
McCormack, J. G., & Denton, R. M. (1980) · Biochemical Journal · doi:10.1042/bj1900095 · Cited by 165
Cited by
NCLX is an essential component of mitochondrial Na+/Ca2+exchange
Palty, R., Silverman, W. F., Hershfinkel, M., Caporale, T., Sensi, S. L., Parnis, J., Nolte, C., Fishman, D., Shoshan-Barmatz, V., Herrmann, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908099107 · Cited by 787
Mitochondria as all‐round players of the calcium game
Rizzuto, R., Bernardi, P., & Pozzan, T. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00037.x · Cited by 560
Regulation of fatty acid oxidation in the mammalian heart in health and disease
Lopaschuk, G. D., Belke, D. D., Gamble, J., Toshiyuki, I., & Schönekess, B. O. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00082-4 · Cited by 554
Mitochondrial calcium exchange in physiology and disease
Garbincius, J. F., & Elrod, J. W. (2022) · Physiological Reviews · doi:10.1152/physrev.00041.2020 · Cited by 412
Na(+) controls hypoxic signalling by the mitochondrial respiratory chain
Hernansanz-Agustín, P., Choya-Foces, C., Carregal-Romero, S., Ramos, E., Oliva, T., Villa-Piña, T., Moreno, L., Izquierdo-Álvarez, A., Cabrera-García, J. D., Cortés, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2551-y · Cited by 238
Metadata
- Authors
- Cox, D. A., & Matlib, M. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 268
- Issue
- 2
- Pages
- 938-947
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1540106294
- Cited by
- 160
- References
- 3
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cox, D. A., & Matlib, M. A. (1993). A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)54024-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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