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Cited by 787

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

NCLX is an essential component of mitochondrial Na+/Ca2+exchange

Open access
Palty, Raz, Silverman, William F., Hershfinkel, Michal, Caporale, Teresa, Sensi, Stefano L., Parnis, Julia, Nolte, Christiane, Fishman, Daniel, Shoshan-Barmatz, Varda, Herrmann, Sharon, Khananshvili, Daniel, Sekler, Israel·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0908099107
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Abstract

Mitochondrial Ca 2+efflux is linked to numerous cellular activities and pathophysiological processes. Although it is established that an Na+-dependent mechanism mediates mitochondrial Ca 2+efflux, the molecular identity of this transporter has remained elusive. Here we show that the Na+/Ca 2+exchanger NCLX is enriched in mitochondria, where it is localized to the cristae. Employing Ca 2+and Na+fluorescent imaging, we demonstrate that mitochondrial Na+-dependent Ca 2+efflux is enhanced upon overexpression of NCLX, is reduced by silencing of NCLX expression by siRNA, and is fully rescued by the concomitant expression of heterologous NCLX. NCLX-mediated mitochondrial Ca 2+transport was inhibited, moreover, by CGP-37157 and exhibited Li+dependence, both hallmarks of mitochondrial Na+-dependent Ca 2+efflux. Finally, NCLX-mediated mitochondrial Ca 2+exchange is blocked in cells expressing a catalytically inactive NCLX mutant. Taken together, our results converge to the conclusion that NCLX is the long-sought mitochondrial Na+/Ca 2+exchanger.

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Metadata

Authors
Palty, R., Silverman, W. F., Hershfinkel, M., Caporale, T., Sensi, S. L., Parnis, J., Nolte, C., Fishman, D., Shoshan-Barmatz, V., Herrmann, S., Khananshvili, D., & Sekler, I.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2009-12-29
Volume
107
Issue
1
Pages
436-441
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0908099107
OpenAlex
W2139625864
Cited by
787
References
32
FWCI
12.12
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: NCLX is an essential component of mitochondrial Na+/Ca2+exchange. https://app.cochat.ai/papers/10.1073/pnas.0908099107
The paper
Palty, R., Silverman, W. F., Hershfinkel, M., Caporale, T., Sensi, S. L., Parnis, J., Nolte, C., Fishman, D., Shoshan-Barmatz, V., Herrmann, S., Khananshvili, D., & Sekler, I. (2010). NCLX is an essential component of mitochondrial Na+/Ca2+exchange. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0908099107

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.