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Cited by 296

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Regulation of purified type I and type II adenylylcyclases by G protein beta gamma subunits.

Open access
Taussig, R., Quarmby, L.M., Gilman, A.G.·1993·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)54106-5
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Abstract

Type I and type II adenylylcyclases have been purified after expression in Sf9 cells, each by application of a two-step purification protocol. The specific activities of the essentially homogeneous enzymes are approximately 7 and 2 mumol.min-1.mg-1, respectively. Each purified enzyme preparation is activated by Gs alpha, but they are regulated in an opposite fashion by G protein beta gamma subunits. Purified beta gamma inhibits Gs alpha-stimulated type I adenylylcyclase directly, while beta gamma activates type II adenylylcyclase and potentiates the Gs alpha-mediated stimulation of the enzyme. This is the first demonstration of the activation of a purified effector molecule by G protein beta gamma subunits.

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Metadata

Authors
Taussig, R., Quarmby, L. M., & Gilman, A. G.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1993-01
Volume
268
Issue
1
Pages
9-12
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)54106-5
OpenAlex
W1535774104
Cited by
296
References
1
FWCI
15.99
Type
journal article
Language
en
Open access
hybrid

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