Sleep and memory: a molecular perspective
Abstract
This review synthesizes data from behavioral studies examining the role of sleep in memory storage with what is known about the molecular mechanisms of memory consolidation. There are striking similarities in the effects on memory storage of post-training pharmacological manipulations and post-training manipulations of sleep. For example, inhibition of protein synthesis is most effective if it occurs at a time post-training when rapid eye movement (REM) sleep is required for memory consolidation. The neurochemical changes that occur across sleep/wake states, especially the cholinergic changes that occur in the hippocampus during REM sleep, might provide a mechanism by which sleep modulates specific cellular signaling pathways involved in hippocampus-dependent memory storage.
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Both monoamines support synaptic remodeling via increasing activity of plasticity related immediate early genes.
“Both monoamines support synaptic remodeling via increasing activity of plasticity related immediate early genes (205,208,475).”
From About Sleep's Role in Memory (2013) · cites this paper as [475]
The effects of cholinergic manipulation are consistent with a role of acetylcholine in synaptic consolidation, e.g., by promoting activity of plasticity-related immediate early genes and maintenance of LTP in cortico-striatal networks.
“The effects are consistent with a role of acetylcholine in synaptic consolidation, e.g., by promoting activity of plasticity-related immediate early genes (475, 615, 1182) and maintenance of LTP in cortico-striatal networks (742).”
From About Sleep's Role in Memory (2013) · cites this paper as [475]
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References 65 · Cited by 216
- Authors
- Graves, L.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Graves, L
- ORCID
- Graves, L
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2001-04-01
- Volume
- 24
- Issue
- 4
- Pages
- 237-243
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2124498150
- Cited by
- 216
- References
- 65
- Citations by year
- 2025: 4 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 3 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 8
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG18199, R01AG018199, T32AG000256)
- National Institute of Mental Health (R01MH060244, MH 60244)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- sleep, memory consolidation, memory storage, REM sleep, protein synthesis inhibition, cholinergic system, hippocampus, sleep-wake states, cellular signaling pathways, hippocampal-dependent memory
- MeSH terms
- Acetylcholine, Animals, Conditioning, Psychological, Hippocampus, Humans, Memory, Protein Synthesis Inhibitors, Serotonin, Sleep, Sleep Deprivation, Sleep, REM, Theta Rhythm, Signal Transduction, Cyclic AMP-Dependent Protein Kinases
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