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Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
Open accessAbstract
Injection of heat-killed bacteria into larvae of the large tenebrionid beetle Zophobas atratus (Insecta, Endopterygota, Coleoptera) results in the appearance in the hemolymph of a potent antibacterial activity as evidenced by a plate growth inhibition assay. We have isolated three peptides (A-C) from this immune hemolymph which probably account for most of this activity. Their primary structures were established by a combination of peptide sequencing and molecular mass determination by mass spectrometry. Peptide A, which is bactericidal against Gram-negative cells, is a 74-residue glycine-rich molecule with no sequence homology to known peptides. We propose the name coleoptericin for this novel inducible antibacterial peptide. Peptides B and C are isoforms of a 43-residue peptide which contains 6 cysteines and shows significant sequence homology to insect defensins, initially reported from dipteran insects. This peptide is active against Gram-positive bacteria. The results are discussed in connection with recent studies on inducible antibacterial peptides present in the three other major orders of the endopterygote clade of insects: the Lepidoptera, Diptera, and Hymenoptera.
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Citations
Cited by
Hoffmann, J. A. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80022-0 · Cited by 572
Self-citationDestoumieux, D., Bulet, P., Loew, D., Van Dorsselaer, A., Rodriguez, J., & Bachère, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28398 · Cited by 441
Self-citationAntimicrobial Peptides Keep Insect Endosymbionts Under Control
Login, F. H., Balmand, S., Vallier, A., Vincent-Monégat, C., Vigneron, A., Weiss-Gayet, M., Rochat, D., & Heddi, A. (2011) · Science · doi:10.1126/science.1209728 · Cited by 354
Fehlbaum, P., Bulet, P., Chernysh, S., Briand, J. P., Roussel, J. P., Letellier, L., Hetru, C., & Hoffmann, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1221 · Cited by 330
Self-citationComparative genomic analysis of the Tribolium immune system
Zou, Z., Evans, J. D., Lu, Z., Zhao, P., Williams, M., Sumathipala, N., Hetru, C., Hultmark, D., & Jiang, H. (2007) · Genome Biology · doi:10.1186/gb-2007-8-8-r177 · Cited by 320
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Metadata
- Authors
- Bulet, P., Cociancich, S., Dimarcq, J. L., Lambert, J., Reichhart, J. M., Hoffmann, D., Hetru, C., & Hoffmann, J. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 266
- Issue
- 36
- Pages
- 24520-24525
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1578374210
- Cited by
- 197
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family. https://app.cochat.ai/papers/10.1016/s0021-9258(18)54260-5
- The paper
- Bulet, P., Cociancich, S., Dimarcq, J. L., Lambert, J., Reichhart, J. M., Hoffmann, D., Hetru, C., & Hoffmann, J. A. (1991). Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)54260-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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