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Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes.
Open accessAbstract
Nerve growth factor (NGF) transcripts were identified in normal human keratinocytes in primary and secondary culture. The expression of the NGF mRNA was strongly down-regulated by corticosteroids and was maximal when keratinocytes were in the exponential phase of growth. Immunofluorescence studies on growing keratinocytes colonies and on elutriated keratinocytes obtained from growing colonies and mature stratified epithelium showed specific staining of the Golgi apparatus only in basal keratinocytes in the exponential phase of growth. The keratinocyte-derived NGF was secreted in a biologically active form as assessed by neurite induction in sensory neurons obtained from chick embryo dorsal root ganglia. Based on these data we suggest that the basal keratinocyte is the cell synthesizing and secreting NGF in the human adult epidermis. The paracrine secretion of NGF by keratinocytes might have a major role in regulating innervation, lymphocyte function, and melanocyte growth and differentiation in epidermal morphogenesis as well as during wound healing.
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Cited by
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
The molecular biology of chronic wounds and delayed healing in diabetes
Blakytny, R., & Jude, E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01773.x · Cited by 632
Nerve growth factor and nociception
Lewin, G. R., & Mendell, L. M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90092-z · Cited by 531
Mechanisms of Ultraviolet Light‐Induced Pigmentation
Gilchrest, B. A., Park, H., Eller, M. S., & Yaar, M. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb02988.x · Cited by 364
Luca, M. D., Siegrist, W., Bondanza, S., Mathor, M., Cancedda, R., & Eberle, A. N. (1993) · Journal of Cell Science · doi:10.1242/jcs.105.4.1079 · Cited by 98
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Metadata
- Authors
- Di Marco, E., Marchisio, P. C., Bondanza, S., Franzi, A. T., Cancedda, R., & De Luca, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 266
- Issue
- 32
- Pages
- 21718-21722
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2428242608
- Cited by
- 172
- References
- 0
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Di Marco, E., Marchisio, P. C., Bondanza, S., Franzi, A. T., Cancedda, R., & De Luca, M. (1991). Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)54695-0
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