The catalytic function of coenzyme A in citric acid synthesis

Novelli, G. David; Lipmann, Fritz.

doi:10.1016/s0021-9258(18)56541-8

Cited by 122Biochemical Acid Research StudiesChemical Reaction MechanismsMicrobial metabolism and enzyme function

The catalytic function of coenzyme A in citric acid synthesis

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Novelli, G. David, Lipmann, Fritz.·1950·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(18)56541-8

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Lipmann et al. elucidated that the two-carbon molecule required for citrate synthesis was acetyl-CoA.
“Later work by Lipmann et al. (35, 36) elucidated that the two-carbon molecule required for citrate synthesis was, in fact, acetyl coenzyme A or acetyl-CoA.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [35]

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Regulation and function of the mammalian tricarboxylic acid cycle
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“(35, 36) elucidated that the two-carbon molecule required for citrate synthesis was, in fact, acetyl coenzyme A or acetyl-CoA.”
Background
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Authors: Novelli, G. D., & Lipmann, F.
Affiliations: Harvard University (US)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1950-01
Volume: 182
Issue: 1
Pages: 213-228
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)56541-8
OpenAlex: W31905407
Cited by: 122
References: 18
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2014: 2
FWCI: 11.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 25852 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords: coenzyme A, citric acid synthesis, citrate synthase, enzyme catalysis, acetyl-CoA, TCA cycle

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The catalytic function of coenzyme A in citric acid synthesis

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