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REVERSIBLE INHIBITION OF THE COUPLING BETWEEN PHOSPHORYLATION AND OXIDATION
Open accessAbstract
Clifton’ was among the first to show that dinitrophenol (DNP) in low concentrations completely blocked synthetic reactions without interfering with oxidation. Other workers have shown that this drug inhibits nitrogen assimilation,2 growth and differentiation: the formation of adaptive enzymes,* and Hotchkiss5 has reported preliminary data showing that DNP prevents phosphate uptake by respiring yeast cells. These results would appear to indicate that DNP acts on the basic mechanism in the cell by which phosphate bond generation is coupled to oxidative reactions.
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Citations
Cited by
Uncoupling: new approaches to an old problem of bioenergetics
Skulachev, V. P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00091-1 · Cited by 893
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476
THE BIOSYNTHESIS OF CHOLESTEROL FROM ACETATE-1-C14 BY CELLULAR FRACTIONS OF RAT LIVER
Bucher, N. L. R., & McGarrahan, K. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50766-9 · Cited by 270
Dinitrophenol and obesity: an early twentieth-century regulatory dilemma
Colman, E. (2007) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2007.03.006 · Cited by 160
Synaptic Vesicles: Selective Depletion in Crayfish Excitatory and Inhibitory Axons
Atwood, H. L., Lang, F., & Morin, W. A. (1972) · Science · doi:10.1126/science.176.4041.1353 · Cited by 147
Metadata
- Authors
- Loomis, W. F., & Lipmann, F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1948-04
- Volume
- 173
- Issue
- 2
- Pages
- 807-808
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2294018174
- Cited by
- 654
- References
- 0
- FWCI
- 28.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: REVERSIBLE INHIBITION OF THE COUPLING BETWEEN PHOSPHORYLATION AND OXIDATION. https://app.cochat.ai/papers/10.1016/s0021-9258(18)57455-x
- The paper
- Loomis, W. F., & Lipmann, F. (1948). REVERSIBLE INHIBITION OF THE COUPLING BETWEEN PHOSPHORYLATION AND OXIDATION. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)57455-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
