Synaptic Vesicles: Selective Depletion in Crayfish Excitatory and Inhibitory Axons

Atwood, Harold L.; Lang, Fred; Morin, Walter A.

doi:10.1126/science.176.4041.1353

Cited by 147Neuroscience and Neuropharmacology ResearchCellular transport and secretionExtracellular vesicles in disease

Synaptic Vesicles: Selective Depletion in Crayfish Excitatory and Inhibitory Axons

Atwood, Harold L., Lang, Fred, Morin, Walter A.·1972·Science

DOI 10.1126/science.176.4041.1353

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Abstract

Stimulation of the excitatory axon of the opener muscle of the crayfish in the presence of the metabolic inhibitor 2,4-dinitrophenol leads to depletion of synaptic vesicles in nerve terminals containing round vesicles. Stimulation of the inhibitory axon under these conditions produces depletion of vesicles in other nerve terminals containing more elongate synaptic vesicles. The experiments show that terminals with round synaptic vesicles are excitatory and that terminals with elongate synaptic vesicles are inhibitory. Replenishment of synaptic vesicles appears to require metabolic energy.

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Self-citation

Authors: Atwood, H. L., Lang, F., & Morin, W. A.
Affiliations: University of Toronto (CA)
Department of Biology, State College, Bridgewater, Massachusetts 02324
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1972-06-23
Volume: 176
Issue: 4041
Pages: 1353-1355
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.176.4041.1353
OpenAlex: W2011090228
Cited by: 147
References: 22
Citations by year: 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2015: 2 · 2013: 1 · 2012: 1
FWCI: 4.36
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: synaptic vesicles, vesicle depletion, 2,4-dinitrophenol, presynaptic terminals, vesicle morphology, synaptic vesicle replenishment, metabolic energy, neuromuscular junction
MeSH terms: Animals, Axons, Astacoidea, Dinitrophenols, Electric Stimulation, Electrophysiology, Membrane Potentials, Microelectrodes, Microscopy, Electron, Synapses, Synaptic Vesicles

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Synaptic Vesicles: Selective Depletion in Crayfish Excitatory and Inhibitory Axons

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