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The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes
Open accessAbstract
Cycloheximide and related glutarimide antibiotics have been shown to affect binding, transfer enzyme II-dependent movement, and release of transfer RNA from the donor site of reticulocyte ribosomes, as well as both the initiation and extension of globin and phenylalanine peptides. They inhibit binding of deacylated tRNAphe to reticulocyte ribosomes in the absence of transfer enzymes at concentrations similar to those that inhibit peptide initiation. These concentrations are below those required for comparable inhibition of peptide extension or transfer enzyme II-dependent translocation of peptidyl-tRNA from the acceptor to the donor ribosomal sites and appear to provide the basis for differential inhibition of peptide initiation and extension.
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Cited by
Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516
Inhibitors of protein synthesis
Vazquez, D. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80689-7 · Cited by 414
Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones
Campbell, D. S., & Holt, C. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00158-2 · Cited by 303
Muckenthaler, M., Gray, N. K., & Hentze, M. W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80282-8 · Cited by 297
Gray, N. K., & Hentze, M. W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06699.x · Cited by 276
Metadata
- Authors
- Obrig, T. G., Culp, W. J., McKeehan, W. L., & Hardesty, B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1971-01
- Volume
- 246
- Issue
- 1
- Pages
- 174-181
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1491060698
- Cited by
- 512
- References
- 0
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes. https://app.cochat.ai/papers/10.1016/s0021-9258(18)62546-3
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- Obrig, T. G., Culp, W. J., McKeehan, W. L., & Hardesty, B. (1971). The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)62546-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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