Iron regulatory protein prevents binding of the 43S translation pre‐initiation complex to ferritin and eALAS mRNAs.
Open accessAbstract
Translation of ferritin and erythroid 5-aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA-protein interactions between iron-responsive elements (IREs) and iron regulatory protein (IRP). In iron-depleted cells, IRP binds to single IREs located in the 5' untranslated regions of ferritin and eALAS mRNAs and represses translation initiation. The molecular mechanism underlying this translational repression was investigated using reconstituted, IRE-IRP-regulated, cell-free translation systems. The IRE-IRP interaction is shown to prevent the association of the 43S translation pre-initiation complex (including the small ribosomal subunit) with the mRNA. Studies with the spliceosomal protein U1A and mRNAs which harbour specific binding sites for this protein in place of an IRE furthermore reveal that the 5' termini of mRNAs are generally sensitive to repressor protein-mediated inhibition of 43S pre-initiation complex binding.
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The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.2.229 · Cited by 3,485 · see citing works
Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation
Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science · doi:10.1126/science.2452485 · Cited by 709 · see citing works
Self-citationMechanism and regulation of eukaryotic protein synthesis
Merrick, W. C. (1992) · Microbiological Reviews · doi:10.1128/mr.56.2.291-315.1992 · Cited by 650 · see citing works
Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Science · doi:10.1126/science.3685996 · Cited by 571 · see citing works
Self-citationObrig, T. G., Culp, W. J., McKeehan, W. L., & Hardesty, B. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62546-3 · Cited by 513 · see citing works
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.
Drapier, J. C., Hirling, H., Wietzerbin, J., Kaldy, P., & Kühn, L. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06038.x · Cited by 401 · see citing works
Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., & Hentze, M. W. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06039.x · Cited by 389 · see citing works
Self-citationIron regulates ferritin mRNA translation through a segment of its 5′-untranslated region.
Aziz, N., & Munro, H. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8478 · Cited by 368 · see citing works
Cox, T. C., Bawden, M. J., Martin, A., & May, B. K. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07715.x · Cited by 360 · see citing works
Dandekar, T., Stripecke, R., Gray, N. K., Goossen, B., Constable, A., Johansson, H. E., & Hentze, M. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07716.x · Cited by 347 · see citing works
Self-citationLevy, S., Avni, D., Hariharan, N., Perry, R. P., & Meyuhas, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3319 · Cited by 344 · see citing works
Haile, D. J., Rouault, T. A., Harford, J. B., Kennedy, M. C., Blondin, G. A., Beinert, H., & Klausner, R. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11735 · Cited by 321 · see citing works
Novel mechanism for translational control in regulation of ferritin synthesis by iron.
Zähringer, J., Baliga, B. S., & Munro, H. N. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.3.857 · Cited by 318 · see citing works
Scherly, D., Boelens, W. C., VENROOIJ, W. J. V., Dathan, N. A., Hamm, J., & Mattaj, I. W. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08601.x · Cited by 309 · see citing works
Haile, D. J., Rouault, T. A., Tang, C., Chin, J., Harford, J. B., & Klausner, R. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7536 · Cited by 270 · see citing works
Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation
Sonenberg, N. (1988) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60614-5 · Cited by 259 · see citing works
Ostareck‐Lederer, A., Ostareck, D. H., Standart, N., & Thiele, B. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06402.x · Cited by 257 · see citing works
Cap recognition and the entry of mRNA into the protein synthesis initiation cycle
Rhoads, R. E. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90028-x · Cited by 256 · see citing works
Hentze, M. W., Rouault, T. A., Caughman, S. W., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.19.6730 · Cited by 249 · see citing works
Self-citationKaminski, A., Howell, M. T., & Jackson, R. J. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07588.x · Cited by 203 · see citing works
Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine.
Kozak, M., & Shatkin, A. J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)46969-x · Cited by 202 · see citing works
Melefors, Ö., Goossen, B., Johansson, H. E., Stripecke, R., Gray, N. K., & Hentze, M. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53414-1 · Cited by 200 · see citing works
Self-citationIdentification of an RNA binding site for human thymidylate synthase.
Chu, E., Voeller, D. M., Koeller, D. M., Drake, J. C., Takimoto, C. H. M., Maley, G. F., Maley, F., & Allegra, C. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.517 · Cited by 178 · see citing works
Both subunits of rat liver ferritin are regulated at a translational level by iron induction
Aziz, N., & Munro, H. N. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.2.915 · Cited by 161 · see citing works
Role of ATP in binding and migration of 40S ribosomal subunits
Kozak, M. (1980) · Cell · doi:10.1016/0092-8674(80)90356-6 · Cited by 153 · see citing works
Goossen, B., & Hentze, M. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.1959-1966.1992 · Cited by 145 · see citing works
Self-citationGoossen, B., Caughman, S. W., Harford, J. B., Klausner, R. D., & Hentze, M. W. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07635.x · Cited by 144 · see citing works
Self-citationGray, N. K., QUICK, S., Goossen, B., Constable, A., Hirling, H., Kühn, L. C., & Hentze, M. W. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18420.x · Cited by 140 · see citing works
Self-citationPurification of a Specific Repressor of Ferritin mRNA Translation from Rabbit Liver
Walden, W. E., Patiño, M. M., & Gaffield, L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80066-7 · Cited by 134 · see citing works
Translational regulation by mRNA/protein interactions in eukaryotic cells: Ferritin and beyond
Melefors, Ö., & Hentze, M. W. (1993) · BioEssays · doi:10.1002/bies.950150203 · Cited by 130 · see citing works
Self-citationEffects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro.
Kozak, M. (1991) · PubMed · Cited by 127 · see citing works
Constable, A., Quick, S., Gray, N. K., & Hentze, M. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4554 · Cited by 127 · see citing works
Self-citationRegulation of protein synthesis by mRNA structure
Gray, N. K., & Hentze, M. W. (1994) · Molecular Biology Reports · doi:10.1007/bf00986961 · Cited by 114 · see citing works
Self-citationWalden, W. E., Daniels-McQueen, S., Brown, P. H., Gaffield, L., Russell, D. A., Bielser, D., Bailey, L. C., & Thach, R. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9503 · Cited by 108 · see citing works
Sonenberg, N., Guertin, D., Cleveland, D., & Trachsel, H. (1981) · Cell · doi:10.1016/0092-8674(81)90398-6 · Cited by 103 · see citing works
Internal initiation of translation of picornavirus RNAs
Jackson, R. J., Hunt, S. L., Gibbs, C. L., & Kaminski, A. (1994) · Molecular Biology Reports · doi:10.1007/bf00986957 · Cited by 98 · see citing works
Anthony, D. D., & Merrick, W. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45981-9 · Cited by 98 · see citing works
Dabeva, M. D., & Warner, J. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36568-8 · Cited by 92 · see citing works
Emery-Goodman, A., Hirling, H., Scarpellino, L., Henderson, B. R., & Kühn, L. C. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.6.1457 · Cited by 89 · see citing works
A competitive inhibitor of the GTP reaction in protein synthesis
Hershey, J. W. B., & Monro, R. E. (1966) · Journal of Molecular Biology · doi:10.1016/s0022-2836(66)80077-3 · Cited by 87 · see citing works
Hammond, M. L., Merrick, W. C., & Bowman, L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1723 · Cited by 64 · see citing works
Stripecke, R., & Hentze, M. W. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.21.5555 · Cited by 59 · see citing works
Self-citationPicornavirus RNA translation continues to surprise
Sonenberg, N. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90440-2 · Cited by 49 · see citing works
Nitric oxide and the post-transcriptional control of cellular iron traffic
Pantopoulos, K., WEISS, G., & Hentze, M. W. (1994) · Trends in Cell Biology · doi:10.1016/0962-8924(94)90179-1 · Cited by 46 · see citing works
Self-citationGene regulation: translational initiation by internal ribosome binding
Oh, S.-K., & Sarnow, P. (1993) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(93)90037-p · Cited by 42 · see citing works
Kempe, E., Muhs, B., & Schäfer, M. (1993) · Developmental Genetics · doi:10.1002/dvg.1020140606 · Cited by 37 · see citing works
Swenson, G. R., Patiño, M. M., Beck, M. M., Gaffield, L., & Walden, W. E. (1991) · BioMetals · doi:10.1007/bf01135557 · Cited by 25 · see citing works
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The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667 · see citing works
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292 · see citing works
Self-citationMolecular mechanisms of translational control
Gebauer, F., & Hentze, M. W. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1488 · Cited by 991 · see citing works
Self-citationFunctional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Leppek, K., Das, R., & Barna, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.103 · Cited by 949 · see citing works
Initiation of Protein Synthesis in Eukaryotic Cells
Pain, V. M. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00747.x · Cited by 712 · see citing works
Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes
Sachs, A. B., Sarnow, P., & Hentze, M. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80268-8 · Cited by 679 · see citing works
Self-citationTargeting RNA with Small Molecules
Thomas, J. R., & Hergenrother, P. J. (2008) · Chemical Reviews · doi:10.1021/cr0681546 · Cited by 644 · see citing works
General Translational Repression by Activators of mRNA Decapping
Coller, J. M., & Parker, R. (2005) · Cell · doi:10.1016/j.cell.2005.07.012 · Cited by 629 · see citing works
Translational control by CPEB: a means to the end
Méndez, R., & Richter, J. D. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35080081 · Cited by 609 · see citing works
Davis, K. L., Martin, E., Turko, I. V., & Murad, F. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.203 · Cited by 585 · see citing works
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works
Ostareck, D. H., Ostareck‐Lederer, A., Wilm, M. S., Thiele, B. J., Mann, M., & Hentze, M. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80241-x · Cited by 503 · see citing works
Self-citationCONTROL OF TRANSLATION INITIATION IN ANIMALS
Gray, N. K., & Wickens, M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.399 · Cited by 500 · see citing works
Self-citationKahvejian, A., Svitkin, Y. V., Sukarieh, R., M'Boutchou, M.-N., & Sonenberg, N. (2005) · Genes & Development · doi:10.1101/gad.1262905 · Cited by 491 · see citing works
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471 · see citing works
Initiation of Protein Synthesis from the A Site of the Ribosome
Wilson, J. E., Pestova, T. V., Hellen, C. U. T., & Sarnow, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00055-6 · Cited by 430 · see citing works
Global regulation of erythroid gene expression by transcription factor GATA-1
Welch, J. J. (2004) · Blood · doi:10.1182/blood-2004-04-1603 · Cited by 408 · see citing works
Binary specification of nonsense codons by splicing and cytoplasmic translation
Thermann, R., Neu‐Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemeier, C., Hentze, M. W., & Kulozik, A. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3484 · Cited by 406 · see citing works
Self-citationTranslational regulation in development
Curtis, D., Lehmann, R., & Zamore, P. D. (1995) · Cell · doi:10.1016/0092-8674(95)90325-9 · Cited by 395 · see citing works
Translation control: bridging the gap between genomics and proteomics?
Pradet‐Balade, B., Boulmé, F., Beug, H., Müllner, E. W., & García‐Sanz, J. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01776-x · Cited by 386 · see citing works
A common function for mRNA 5' and 3' ends in translation initiation in yeast.Preprint
Tarun, S. Z., & Sachs, A. B. (1995) · Genes & Development · doi:10.1101/gad.9.23.2997 · Cited by 374 · see citing works
Rapid responses to oxidative stress mediated by iron regulatory protein.
Pantopoulos, K., & Hentze, M. W. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07291.x · Cited by 328 · see citing works
Self-citationDrosophila miR2 induces pseudo-polysomes and inhibits translation initiation
Thermann, R., & Hentze, M. W. (2007) · Nature · doi:10.1038/nature05878 · Cited by 314 · see citing works
Self-citationOexle, H., Gnaiger, E., & Weiss, G. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00088-2 · Cited by 307 · see citing works
Muckenthaler, M., Gray, N. K., & Hentze, M. W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80282-8 · Cited by 297 · see citing works
Self-citationIron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome
Guo, B., Phillips, J. D., Yu, Y., & Leibold, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21645 · Cited by 287 · see citing works
Nichol, H., Law, J. H., & Winzerling, J. J. (2002) · Annual Review of Entomology · doi:10.1146/annurev.ento.47.091201.145237 · Cited by 279 · see citing works
Tunable protein synthesis by transcript isoforms in human cells
Floor, S. N., & Doudna, J. A. (2016) · eLife · doi:10.7554/elife.10921 · Cited by 265 · see citing works
The Splicing Factor SF2/ASF Regulates Translation Initiation by Enhancing Phosphorylation of 4E-BP1
Michlewski, G., Sanford, J. R., & Cáceres, J. F. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.013 · Cited by 277 · see citing works
Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast
Preiß, T., & Hentze, M. W. (1998) · Nature · doi:10.1038/33192 · Cited by 270 · see citing works
Self-citationOstareck, D., Ostareck-Lederer, A., Shatsky, I., & Hentze, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00212-4 · Cited by 280 · see citing works
Self-citationDecapping Activators in Saccharomyces cerevisiae Act by Multiple Mechanisms
Nissan, T. A., Rajyaguru, P. I., She, M., Song, H., & Parker, R. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.025 · Cited by 245 · see citing works
Iron regulatory proteins and their role in controlling iron metabolism
Kühn, L. C. (2015) · Metallomics · doi:10.1039/c4mt00164h · Cited by 242 · see citing works
Hoyle, N. P., Castelli, L. M., Campbell, S. G., Holmes, L. E. A., & Ashe, M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200707010 · Cited by 239 · see citing works
Regulation of Iron Metabolism in Eukaryotes
Rouault, T. A., & Klausner, R. D. (1997) · Current topics in cellular regulation · doi:10.1016/s0070-2137(97)80001-5 · Cited by 239 · see citing works
Multiple portions of poly(A)‐binding protein stimulate translation in vivo
Gray, N. K., Coller, J. M., Dickson, K. S., & Wickens, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4723 · Cited by 236 · see citing works
Self-citationZhou, Z., & Tan, E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0218-4 · Cited by 229 · see citing works
Translational pathophysiology: a novel molecular mechanism of human disease
Cazzola, M., & Skoda, R. C. (2000) · Blood · doi:10.1182/blood.v95.11.3280 · Cited by 222 · see citing works
Dendritic BC1 RNA: Functional Role in Regulation of Translation Initiation
Wang, H., Iacoangeli, A., Popp, S., Muslimov, I., Imataka, H., Sonenberg, N., Lomakin, I., & Tiedge, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10232.2002 · Cited by 232 · see citing works
Pantopoulos, K., & Hentze, M. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1267 · Cited by 220 · see citing works
Self-citationFuruyama, K., Kaneko, K., & V., P. D. V. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.213.1 · Cited by 210 · see citing works
Pantopoulos, K., Weiss, G., & Hentze, M. W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3781 · Cited by 195 · see citing works
Self-citationAddess, K. J., Basilion, J. P., Klausner, R. D., Rouault, T. A., & Pardi, A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1377 · Cited by 194 · see citing works
Iron homeostasis: An anthropocentric perspective
Coffey, R., & Ganz, T. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.781823 · Cited by 189 · see citing works
Gray, N. K., Pantopoulos, K., Dandekar, T., Ackrell, B. A. C., & Hentze, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4925 · Cited by 187 · see citing works
Self-citationAbnormal localization of iron regulatory protein in Alzheimer’s disease
Smith, M. A., Wehr, K., Harris, P. L. R., Siedlak, S. L., Connor, J. R., & Perry, G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00002-x · Cited by 162 · see citing works
Tidu, A., Janvier, A., Schaeffer, L., Sosnowski, P., Kühn, L., Hammann, P., Westhof, É., Eriani, G., & Martin, F. (2020) · RNA · doi:10.1261/rna.078121.120 · Cited by 162 · see citing works
Costa‐Mattioli, M., Svitkin, Y. V., & Sonenberg, N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6861-6870.2004 · Cited by 159 · see citing works
Leedman, P. J., Stein, A. R., Chin, W. W., & Rogers, J. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.12017 · Cited by 154 · see citing works
[19] Optimized synthesis of RNA-protein fusions for in vitro protein selection
Liu, R., Barrick, J. E., Szostak, J. W., & Roberts, R. W. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)18058-9 · Cited by 153 · see citing works
Stripecke, R., Oliveira, C. C., McCarthy, J. E. G., & Hentze, M. W. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5898-5909.1994 · Cited by 153 · see citing works
Self-citationMolecular Regulation of Heme Biosynthesis in Higher Vertebrates
May, B. K., Dogra, S. C., Sadlon, T., Bhasker, C. R., Cox, T. C., & Bottomley, S. S. (1995) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60875-2 · Cited by 148 · see citing works
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2Preprint
Zhang, Y., Qian, Y., Zhang, J., Yan, W., Jung, Y.-S., Chen, M., Huang, E. C., Lloyd, K. C. K., Duan, Y., Wang, J., et al. (2017) · Genes & Development · doi:10.1101/gad.299388.117 · Cited by 151 · see citing works
Tailor made: the art of therapeutic mRNA design
Metkar, M., Pepin, C. S., & Moore, M. J. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00827-x · Cited by 153 · see citing works
Cytoplasmic mRNA-protein interactions in eukaryotic gene expression
McCarthy, J. E. G., & Kollmus, H. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89006-4 · Cited by 146 · see citing works
Nucleo-Mitochondrial Interactions in Mitochondrial Gene Expression
Grivell, L. A. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509085141 · Cited by 145 · see citing works
Retinoic acid-gated sequence-specific translational control by RARα
Poon, M. M., & Chen, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807740105 · Cited by 138 · see citing works
Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.
Butt, J., Kim, H. Y., Basilion, J. P., Cohen, S., Iwaï, K., Philpott, C. C., Altschul, S. F., Klausner, R. D., & Rouault, T. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4345 · Cited by 139 · see citing works
Dendritic BC1 RNA in translational control mechanisms
Wang, H., Iacoangeli, A., Lin, D., Williams, K. L., Denman, R. B., Hellen, C. U. T., & Tiedge, H. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506006 · Cited by 137 · see citing works
Gebauer, F., Corona, D. F. V., Preiß, T., Becker, P. B., & Hentze, M. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6146 · Cited by 134 · see citing works
Self-citationBrain iron overload following intracranial haemorrhage
Garton, T. P., Keep, R. F., Hua, Y., & Xi, G. (2016) · Stroke and Vascular Neurology · doi:10.1136/svn-2016-000042 · Cited by 131 · see citing works
Characterization and Expression of Iron Regulatory Protein 2 (IRP2)
Guo, B., Brown, F. M., Phillips, J. D., Yu, Y., & Leibold, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16529 · Cited by 129 · see citing works
Interplay between NO and [Fe-S] Clusters: Relevance to Biological Systems
Drapier, J. (1997) · Methods · doi:10.1006/meth.1996.0426 · Cited by 128 · see citing works
Kohler, S. A., Henderson, B. R., & Kühn, L. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30781 · Cited by 125 · see citing works
Poly(A)-tail-promoted translation in yeast: Implications for translational control
PREISS, T., MUCKENTHALER, M., & HENTZE, M. W. (1998) · RNA · doi:10.1017/s1355838298980669 · Cited by 123 · see citing works
Self-citationAllerson, C. R., Cazzola, M., & Rouault, T. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26439 · Cited by 122 · see citing works
Yang, H., Yao, X., Liu, Y., Shen, X., Li, M., & Luo, Z. Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c04632 · Cited by 120 · see citing works
Castagnetti, S., & Ephrussi, A. (2003) · Development · doi:10.1242/dev.00309 · Cited by 119 · see citing works
Somerville, G. A., Cockayne, A., Dürr, M. C., Peschel, A., Otto, M. J., & Musser, J. M. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.22.6686-6694.2003 · Cited by 119 · see citing works
Meng, Z. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki603 · Cited by 116 · see citing works
MicroRNAs Mediate Gene Silencing via Multiple Different Pathways in Drosophila
Fukaya, T., & Tomari, Y. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.024 · Cited by 116 · see citing works
Inhibition of translation by RNA–small molecule interactions
Harvey, I., Garneau, P., & Pelletier, J. (2002) · RNA · doi:10.1017/s135583820202633x · Cited by 116 · see citing works
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila.
Beckmann, K., Grs̆ković, M., Gebauer, F., & Hentze, M. (2005) · Cell · doi:10.1016/j.cell.2005.06.011 · Cited by 115 · see citing works
Self-citationAutoregulation of poly(A)-binding protein synthesisin vitro
Neto, O. P. D. M., Standart, N., & de, C. M. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2198 · Cited by 111 · see citing works
eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition
Simonetti, A., Querido, J. B., Myasnikov, A. G., Mancera-Martínez, E., Renaud, A., Kühn, L., & Hashem, Y. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.033 · Cited by 109 · see citing works
Merrill, M. K., & Gromeier, M. (2006) · Journal of Virology · doi:10.1128/jvi.00243-06 · Cited by 107 · see citing works
Ironing out the details of ferroptosis
Zhang, D. D. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01361-7 · Cited by 108 · see citing works
Ribosome profiling reveals an important role for translational control in circadian gene expressionPreprint
Jang, C. J., Lahens, N. F., Hogenesch, J. B., & Sehgal, A. (2015) · Genome Research · doi:10.1101/gr.191296.115 · Cited by 106 · see citing works
Regulation of iron pathways in response to hypoxia
Chepelev, N. L., & Willmore, W. G. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.023 · Cited by 102 · see citing works
Pellizzoni, L., Lotti, F., Maras, B., & Pierandrei‐Amaldi, P. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0888 · Cited by 103 · see citing works
Berchowitz, L. E., Gajadhar, A. S., van Werven, F. J., Rosa, A. A. D., Samoylova, M. L., Brar, G. A., Xu, Y.-F., Xiao, C., Futcher, B., Weissman, J. S., et al. (2013) · Genes & Development · doi:10.1101/gad.224253.113 · Cited by 102 · see citing works
Regulation of Iron Metabolism: Translational Effects Mediated by Iron, Heme, and Cytokines
Mascotti, D. P., Rup, D., & Thach, R. E. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001323 · Cited by 97 · see citing works
Sheikh, N., Dudás, J., & Ramadori, G. P. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700553 · Cited by 93 · see citing works
Differential Modulation of the RNA-binding Proteins IRP-1 and IRP-2 in Response to Iron
Henderson, B. R., & Kühn, L. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20509 · Cited by 95 · see citing works
L13a Blocks 48S Assembly: Role of a General Initiation Factor in mRNA-Specific Translational Control
Kapasi, P., Chaudhuri, S., Vyas, K., Baus, D., Komar, A. A., Fox, P. L., Merrick, W. C., & Mazumder, B. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.028 · Cited by 94 · see citing works
Tejedor, J. R., Papasaikas, P., & Valcárcel, J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.029 · Cited by 91 · see citing works
Gebauer, F., Merendino, L., Hentze, M. W., & Valcárcel, J. (1998) · Europe PMC (PubMed Central) · Cited by 92 · see citing works
Self-citationBarkoff, A. F., Dickson, K. S., Gray, N. K., & Wickens, M. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9613 · Cited by 91 · see citing works
Self-citation5-Aminolevulinate synthase and the first step of heme biosynthesis
Ferreira, G. C., & Gong, J. (1995) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110030 · Cited by 90 · see citing works
Estrogen Regulates Adrenal Angiotensin AT 1 Receptors by Modulating AT 1 Receptor Translation
Wu, Z., Maric, C., Roesch, D. M., Zheng, W., Verbalis, J. G., & Sandberg, K. L. (2003) · Endocrinology · doi:10.1210/en.2003-0015 · Cited by 89 · see citing works
Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependent
Gregorio, E. D., Preiß, T., & Hentze, M. W. (1998) · RNA · doi:10.1017/s1355838298980372 · Cited by 89 · see citing works
Self-citationProtein-protein interactions required during translation
Gallie, D. (2002) · Plant Molecular Biology · doi:10.1023/a:1021220910664 · Cited by 87 · see citing works
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Castagnetti, S., Hentze, M. W., Ephrussi, A., & Gebauer, F. (2000) · Development · doi:10.1242/dev.127.5.1063 · Cited by 87 · see citing works
Self-citationMulero, V., & Brock, J. H. (1999) · Blood · doi:10.1182/blood.v94.7.2383.419k20_2383_2389 · Cited by 86 · see citing works
Redox Modulation of Iron Regulatory Proteins by Peroxynitrite
Bouton, C., Hirling, H., & Drapier, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19969 · Cited by 85 · see citing works
Systemic iron metabolism: a review and implications for brain iron metabolism
Rouault, T. A. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00260-0 · Cited by 81 · see citing works
Translational controls impinging on the 5′-untranslated region and initiation factor proteins
Jackson, R. J., & Wickens, M. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80133-5 · Cited by 81 · see citing works
Kim, H., Klausner, R. D., & Rouault, T. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.4983 · Cited by 81 · see citing works
Drosophila Sex-Lethal Inhibits the Stable Association of the 40S Ribosomal Subunit with msl-2 mRNA
Gebauer, F., Grs̆ković, M., & Hentze, M. W. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00176-x · Cited by 77 · see citing works
Self-citation
- Authors
- Gray, N. K., & Hentze, M. W.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Venue
- The EMBO Journal
- Published
- 1994-08-01
- Volume
- 13
- Issue
- 16
- Pages
- 3882-3891
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC395301
- OpenAlex
- W70018918
- Cited by
- 276
- References
- 47
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 2 · 2012: 4
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- iron regulatory proteins, iron-responsive element, ferritin mRNA, protein synthesis inhibition, mRNA-protein interactions, 5' untranslated region, U1A, small ribosomal subunit, cell-free translation system
- MeSH terms
- 5-Aminolevulinate Synthetase, Animals, Cell-Free System, Ferritins, Models, Genetic, Peptide Chain Initiation, Translational, Protein Binding, Rabbits, Regulatory Sequences, Nucleic Acid, Repressor Proteins, Reticulocytes, Ribosomes, RNA, Messenger, Chloramphenicol O-Acetyltransferase, RNA-Binding Proteins, Ribonucleoprotein, U1 Small Nuclear, Genes, Reporter, Iron-Regulatory Proteins
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