The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Enzymatic O-Methylation of Epinephrine and Other Catechols
Open accessOverview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The O-methylation of catechols plays an important role in the phase 2 metabolism of estrogens (Section 4.4.1) and is catalyzed by the enzyme catechol-O-methyltransferase (COMT) [179]”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [179]
Citations
Cites
ON TYROSINE AND TRYPTOPHANE DETERMINATIONS IN PROTEINS
Folin, O., & Ciocalteu, V. (1927) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84277-6 · Cited by 2,990
The chemical estimation of adrenaline-like substances in blood
Weil‐Malherbe, H., & Bone, A. D. (1952) · Biochemical Journal · doi:10.1042/bj0510311 · Cited by 481
O-Methylation of Epinephrine and Other Catechols in vitro and in vivo
Axelrod, J. (1957) · Science · doi:10.1126/science.126.3270.400 · Cited by 362
3-Methoxy-4-hydroxy-D-mandelic acid, a urinary metabolite of norepinephrine
Armstrong, M. D., McMillan, A., & Shaw, K. N. F. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90491-2 · Cited by 353
O-Methylation of Catechol Amines in Vivo
Axelrod, J., Senoh, S., & Witkop, B. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64730-1 · Cited by 207
METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER
Cantoni, G. L. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56110-x · Cited by 197
URINARY METABOLITES OF CAFFEIC AND CHLOROGENIC ACIDS
Booth, A. N., Emerson, O. H., Jones, F. T., & DeEds, F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70592-9 · Cited by 181
THE METABOLISM OF 3,4-DIHYDROXYPHENYLALANINE
Shaw, K. N. F., McMillan, A., & Armstrong, M. D. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64827-6 · Cited by 138
O-methylation, the principal pathway for the metabolism of epinephrine and norepinephrine in the rat
Axelrod, J., Inscoe, J. K., Senoh, S., & Witkop, B. (1958) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(58)90316-0 · Cited by 121
ENZYMATIC MECHANISM OF CREATINE SYNTHESIS
Cantoni, G. L., & Vignos, P. J. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65492-4 · Cited by 117
Research works printed but not linked: 5
- von Etiler, 1955, Acta Physiol-Scand., 33, 118
- Cantoni, 1957, 3, 600
- von Euler, 1955, Acta Physiol. Scand., 33, 118, 45
- Warburg, 1941, Biochem. Z., 310, 384
- LaBrosse, 1958, Federation Proc., 17, 386
Cited by
Sorted by citations
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine
Peuler, J. D., & Johnson, G. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90070-4 · Cited by 1,899
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675
“Since its discovery in 1958 (Axelrod and Tomchick 1958), catechol-O-methyltransferase (COMT) has been an important enzyme in catecholamine biochemistry and pharmacology and, more recently, in genetic mechanisms of variation in catechol metabolism and its clinical implications.”
BackgroundPrada, M. D., & Zürcher, G. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90251-4 · Cited by 1,174
Metadata
- Authors
- Axelrod, J., & Tomchick, R.
- Affiliations
- United States Public Health Service (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1958-09
- Volume
- 233
- Issue
- 3
- Pages
- 702-705
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1543624067
- Cited by
- 1,283
- References
- 16
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 19 · 2020: 11 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 28 · 2015: 12 · 2014: 14 · 2013: 19 · 2012: 21
- FWCI
- 55.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- epinephrine, catechol, O-methylation, enzymatic methylation, catecholamine metabolism
- MeSH terms
- Catechols, Epinephrine, Methylation, Norepinephrine, Transferases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
