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Enzymatic O-Methylation of Epinephrine and Other Catechols
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“The O-methylation of catechols plays an important role in the phase 2 metabolism of estrogens (Section 4.4.1) and is catalyzed by the enzyme catechol-O-methyltransferase (COMT) [179]”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [179]
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“Since its discovery in 1958 (Axelrod and Tomchick 1958), catechol-O-methyltransferase (COMT) has been an important enzyme in catecholamine biochemistry and pharmacology and, more recently, in genetic mechanisms of variation in catechol metabolism and its clinical implications.”
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“COMT primarily methylates the 2 or 4 position of the catechol substrate [181,182].”
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“Catechol-O-methyltransferase (COMT) (Axelrod and Tomchick, 1958) methylates catechol structures, including dopamine (DA), norepinephrine (NE), epinephrine, caffeine, and catechol estrogens.”
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“correct DFT xc functionals to investigate the convergence of key catalytic properties with increasing QM region size using the model system, catechol O-methyltransferase (COMT).(77)”
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“Catechol O-methyltransferase (COMT) inactivates catecholamines (4) and therefore could be a factor in regulating aggressive behavior.”
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Is COMT a Susceptibility Gene for Schizophrenia?
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“In the context of either hypothesis, the COMT gene encoding catechol-O-methyl transferase (COMT) is a clear functional candidate gene for schizophrenia because COMT is involved in the catabolic clearance of dopamine.(5) COMT maps to chromosome 22q11.”
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“Aside from the study by Bowers and colleagues, evidence to date suggests that peripheral and central HVA levels are lower during BN. Reduced HVA levels are typically considered an index of reduced dopamine function and reduced dopamine turnover (dopamine to HVA ratio).”
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“For instance, since COMT also plays an important role in degrading norepinephrine and epinephrine [7], it has been suggested that presence of the Val allele may promote more rapid degradation of”
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“However, the catechol-O-methyltransferase (COMT) gene, which codes for one of the major methylation enzymes metabolizing monoaminergic neurotransmitters including dopamine [Axelrod and Tomchick, 1958], has repeatedly been suggested as a promising candidate gene in the pathogenesis of the disorder.”
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“The COMT gene encodes catechol-O-methyltransferase, which catabolizes brain catecholamine neurotransmitters such as dopamine and norepinephrine (2).”
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“localized monoamine oxidase (MAO), acts as a key degradative enzyme of numerous neuroactive monoamines including dopamine (DA) (Axelrod and Tomchick, 1958).”
BackgroundImmunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain
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Human kidney thiopurine methyltransferase purification and biochemical properties
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The Nature and Function of Lignins
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Crystal Structures of Human 108V and 108M Catechol O-Methyltransferase
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Metadata
- Authors
- Axelrod, J., & Tomchick, R.
- Affiliations
- United States Public Health Service (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1958-09
- Volume
- 233
- Issue
- 3
- Pages
- 702-705
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1543624067
- Cited by
- 1,283
- References
- 16
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 19 · 2020: 11 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 28 · 2015: 12 · 2014: 14 · 2013: 19 · 2012: 21
- FWCI
- 55.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- epinephrine, catechol, O-methylation, enzymatic methylation, catecholamine metabolism
- MeSH terms
- Catechols, Epinephrine, Methylation, Norepinephrine, Transferases
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